Best CBD Oil For Lung Cancer


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Based on the positive findings of a recent case study, CBD oil is a promising alternative to traditional treatments for lung cancer. CBD oil can be used to help alleviate the symptoms and side effects of cancer treatments. However, there has been limited research on whether CBD oil can cure or be used to treat cancer to date. Striking lung cancer response to self-administration of cannabidiol: A case report and literature review This article is distributed under the terms of the Creative Commons

CBD Oil and Lung Cancer: Case Report Highlights Plant’s Medicinal Potential

Were you aware of the fact that lung cancer is the leading global cause of cancer death? This is according to the Lung Cancer Research Foundation , which also claims that 130,180 American lives are lost to the deadly disease every year. Fortunately, the incidence rate of lung cancer is declining steadily in men (2.8% annually) and women (1.4% annually) across the United States.

Cannabis, a plant with many uses in the medical field, could help to shrink tumors in lung cancer patients. This is based on previous studies and a recent study that was featured in BMJ Journals .

Doctors Observe Patient’s Tumor Regression

The subject of using cannabis to treat cancer is being discussed more openly nowadays, with more success stories transpiring all of the time. One of the more recent medical cannabis success stories was presented by a team of researchers who followed the story of a girl who self-administered cannabidiol (CBD) 2-3 times per day.

Titled “ Lung cancer patient who had declined conventional cancer treatment: could the self-administration of ‘CBD oil’ be contributing to the observed tumor regression? , ” the case report was published on Oct. 14, 2021. As noted by the researchers, lung cancer patients are usually treated with a mixture of methods, such as chemotherapy, radiotherapy, and surgery. Unfortunately, such treatments usually prove difficult to bear for the people who undergo them.

When offered conventional lung cancer treatment, the patient who was presented in this recently published case report refused— a decision that potentially saved her life. After self-administering CBD oil, which is a psychoactive but non-intoxicating extract of the cannabis plant, the patient and doctors observed her cancerous tumor shrinking over the course of two-and-a-half years to just 10 millimeters. Before using CBD for lung cancer, the patient’s tumor measured 41 millimeters.

Cannabinoids Prove to Be Promising for Cancer

Cannabis compounds, better known as “cannabinoids,” are not chemically dissimilar to the endocannabinoids that are naturally produced by the human body. Both types of chemicals can react with signaling pathways in the endocannabinoid system (ECS).

Once the pathways are triggered, they influence a broad range of mechanisms inside the human body, including how cancer cells function. In simple terms, cannabinoids are capable of regulating the way in which cells receive, send, and process messages.

Cannabinoids are being used more frequently in palliative care than ever before. Examples of some potential benefits of cannabinoids in cancer care include increased appetite, reduced nausea, and pain relief. What’s more, the anti-tumor effects of cannabinoids have been demonstrated in a growing number of animal studies.

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The great thing about cannabinoids is that they can be administered in a variety of ways, including orally, topically, and sublingually. One of the most impressive of all 114 cannabinoids that have, so far, been identified by scientists is CBD. Unlike tetrahydrocannabinol (THC), CBD is non-intoxicating.

Studies into CBD have shown that the cannabis compound possesses antiproliferative effects , meaning that it can inhibit cell-cycle pathways and cause apoptosis in various cells, including cancer cells. CBD, which generated $4.6 billion in revenue for the U.S. economy last year alone, also has pro-apoptotic effects .

Understanding the Main Causes of Lung Cancer

The first step to preventing lung cancer and caring for your health is quitting cigarette smoking (if you do). Based on statistics published by the Centers for Disease Control and Prevention (CDC) , cigarette smoking is the leading risk factor for lung cancer. (It should be noted that while smoking cannabis has other risks, it has not been linked to lung cancer.)

In the U.S. alone, between 80% and 90% of lung cancer deaths are associated with cigarette smoke. Someone’s chances of being diagnosed with the often fatal disease also soar with the regular use of pipes, cigars, and other tobacco products, which are plagued with thousands of harmful chemicals.

Secondhand smoke is also a common culprit of lung cancer, as is radon— a type of gas that occurs naturally in water, soil, and rocks. If estimates from the U.S. Environmental Protection Agency (EPA) are correct, radon kills as many as 21,000 lung cancer patients on an annual basis.

Your risk of developing lung cancer is also likely to increase if your relatives, such as your mother and father, brothers or sisters, or children have been diagnosed with the disease at some point in their lives. There’s also a higher risk of lung cancer among cancer survivors who have had radiation therapy to the chest.


Chronic pain is the most commonly reported reason for patients who use medical cannabis. But this isn’t to say that medical cannabis can only benefit chronic pain patients. There are more cannabinoid receptors than other types of receptors in the brain, meaning that cannabis may work as the missing puzzle piece for patients who endure a broad spectrum of illnesses and diseases, including lung cancer.

Studies carried out in the past have drawn mixed conclusions on the subject of cannabinoids as a cancer treatment. However, the BMJ Journals case report clearly indicates that CBD oil is connected with tumor regression. On the other hand, more research is needed to fully understand the connection between cannabis and lung cancer.

CBD Oil for Lung Cancer: Is Cannabis A Potential Treatment?

Lung cancer is the second most common form of cancer in the U.S. Sadly, it is estimated that more than 130,000 Americans will succumb to lung cancer in 2021.

Traditional treatments are widely regarded as being extremely difficult and painful to undergo. This fact, combined with the deadly threat posed by cancer, has contributed to a surge in research into new therapies and treatments for cancer worldwide.

One such area in treating cancer is the promising use of CBD oil. Several research studies have provided insight that using CBD oil may help prevent cancer growth. While more research is needed in this area, CBD oil is already being used to help manage the symptoms of cancer and the adverse health effects of various cancer treatments.

Are All Cannabis Oils the Same?

There are many different types of cannabis oils:

CBD Oil. This oil is nonpsychoactive, meaning that it will not produce any feeling of being “high.” This is due to the fact that CBD oil doesn’t contain THC, which is the compound responsible for giving users such a sensation. CBD is valued for its many health benefits, which include easing pain, anxiety, and the side effects of going through chemotherapy.

There are three main types of CBD oil:

  • Broad-spectrum CBD oil
  • Full-spectrum CBD oil
  • CBD oil derived from CBD isolate
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Hemp Seed Oil. Hemp is a plant that is very similar to cannabis, with the key difference being that it does not contain THC or other important cannabinoids. Hemp seed oil is mainly used in skincare products or as a cooking oil.

Marijuana-derived oil. This type of oil is made from dried marijuana buds and leaves. As a result, it has a higher ratio of THC than other types of cannabis oils like CBD oil or hemp-derived oil.

Rick Simpson Oil. This type of oil features high levels of THC with a varying CBD content depending on the formulation.

For Health and Safety, Choose CBD Oil

When you’re looking for health benefits, it is CBD you want to emphasize when choosing a cannabis oil. Broad-spectrum CBD oil does not contain any THC, whereas full-spectrum CBD oil will have some THC present — but not more than 0.3%. CBD oil made from isolate involves a process of extracting all compounds from the cannabis plant. This process produces pure CBD in a crystal form which may be ground into a powder so that products are more convenient for consumption.

Can You Use CBD Oil to Treat Cancer?

There has been a push for research on whether CBD oil can help cure cancer. To date, there are many reports that CBD has helped people in dealing with this disease. But most of these reports are anecdotal evidence rather than scientific research. There isn’t any way to confirm the reliability of these stories or whether other treatments may have contributed to these positive experiences.

Most of the scientific research is still in its early stages in exploring whether CBD use is an effective cancer treatment. But there have been some positive findings.

A 2019 study found that CBD and cannabis extracts may cause the death of cancerous cells and may enhance the efficacy of radiation treatment. Other studies have also found that CBD in conjunction with THC may improve the effectiveness of radiation treatment in patients.

A specific case was reported in 2019 concerning a man with lung cancer. He declined traditional treatments and opted for the use of CBD oil instead. His tumor seemed to react favorably to CBD oil treatment.

But it is too early to definitively declare that CBD has any positive effects on preventing or treating lung cancer.

However, there are other areas in which the use of CBD oil can help people cope with lung cancer.

Does the Use of CBD Oil Help with Cancer Symptoms?

It is difficult to say whether CBD oil can help in cancer treatment, given that there is limited research in this area. However, there are various research findings that suggest CBD use can be extremely valuable for patients dealing with cancer and cancer treatments.

Cancer treatment typically involves chemotherapy or radiation therapy. Both of these treatment options take a heavy toll on the human body.

The use of CBD oil can help with various side effects of lung cancer treatment, including:

  • Pain
  • Fatigue
  • Reduced appetite
  • Nausea

CBD has been found to provide relief from chronic pain. This benefit of CBD use can be extremely valuable for cancer patients undergoing intense chemotherapy or radiation treatments.

Nausea is another common side effect of cancer treatment options. CBD has been found to lower the symptoms of nausea resulting from chemotherapy.

Does CBD Oil Use Come with any Side Effects?

CBD oil is generally safe to take. When using CBD, the side effects are predominantly mild and may include:

  • Dry mouth
  • Drowsiness
  • Diarrhea
  • Anxiety
  • Changes in appetite

Like any compound, CBD oil may interact with any medication you are currently taking. As a precaution, you should consult with your doctor if you are considering using CBD while already taking prescription medication.

How Is CBD Oil Used?

Products infused with CBD generally fall into one of four categories that depend on the way they are used.

Ingesting CBD

There are many benefits to consuming CBD, which may help explain why there are so many options to choose from on the market today. Ingesting these products means that the CBD passes through your digestive system and gets metabolized by your liver. This enables the CBD you ingest to be provided all over your body over a period of a few hours.

Products in this category include capsules, tinctures, or drops and can be added to food or mix with coffee or tea.

Sublingual CBD

Alternatively, you can take CBD oil using a sublingual method. This involves placing a few drops of CBD oil under your tongue and holding it there for up to 60 seconds. This method allows the important compounds to be quickly absorbed into your bloodstream and dispersed throughout your body.

Topical CBD

To reduce any inflammation or relieve the pain you may experience, look for topical CBD products as they work the best. They give you the flexibility to apply them directly to whichever parts of your body need some relief. Topical CBD products include salves, shampoos, lip balms, creams, patches, suppositories, personal lubricants, and bath salts.

Inhaled CBD

Another popular way to take CBD is to inhale its vapors using vape carts and pens. This way, CBD enters your bloodstream quickly through your lungs and avoids the digestive system altogether. In particular, vaping has been growing in popularity with CBD use due to its ease of use and variety of flavors and options.

For CBD use with lung cancer, it is important to discuss your options with your doctor. This is particularly important for inhaling CBD.

Where Can I Buy CBD Oil?

With the passing of the 2018 Farm Bill, cannabis products are legal, theoretically, at the federal level as long as they contain less than 0.3% Delta 9 THC. As a result, many dispensaries and stores now carry a wide selection of CBD oils and other products.

If you prefer the many advantages of online shopping for your CBD oil, you have countless options to choose from. But keep in mind that CBD oils, for the most part, are largely unregulated. Therefore, you need to guarantee that your product is safe and effective.

According to a recent study, less than one in three CBD products that were sold online had a correct label, with many of these products having less CBD content than advertised or had a significant concentration of THC.

So be sure to carefully research the company and its products before buying.

Key Takeaways on Using CBD Oil for Lung Cancer

There isn’t enough research to declare that CBD oil is effective as a treatment option for cancer. However, CBD may be able to offer some relief from the side effects of traditional treatments and from the symptoms of cancer.

It is a good idea to continue following the advice of your health care provider, even if your CBD oil seems to be giving you positive effects. Otherwise, stopping ongoing procedures could make future treatments more difficult and negatively impact your ability to treat tumors.

CBD oil is a promising ally in your battle with lung cancer. As more research becomes available, CBD oil may prove to be a viable treatment for your health needs.


  1. Dariš, B., Tancer Verboten, M., Knez, Ž., & Ferk, P. (2019). Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosnian journal of basic medical sciences, 19(1), 14–23.(1)
  2. Ivanov, V. N., Wu, J., Wang, T., & Hei, T. K. (2019). Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells. Oncotarget, 10(8), 825–846.(2)
  3. Scott K., Dalgleish A, & Liu W. (2014).The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Mol Cancer Ther December 1 2014 (13) (12) 2955-2967; DOI: 10.1158/1535-7163.MCT-14-0402 (3)
  1. Sulé-Suso1 J., 2, Watson N., van Pittius D., & Jegannathen A. (2019). Striking lung cancer response to self-administration of cannabidiol: A case report and literature review. Sage Open Medical Case Reports.First Published February 21, 2019. (4)
  2. Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, K. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in pharmacology, 11, 561. (5)
  3. Rock, E. M., Sticht, M. A., Limebeer, C. L., & Parker, L. A. (2016). Cannabinoid Regulation of Acute and Anticipatory Nausea. Cannabis and cannabinoid research, 1(1), 113–121.(6)
  4. Bonn-Miller, M., Loflin, M., Thomas, B., Marcu,J., Hyke, T., Vandrey, R. (2017) Labeling Accuracy of Cannabidiol Extracts Sold Online. JAMA. 2017;318(17):1708-1709. doi:10.1001/jama.2017.11909 (7)
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Nina Julia

Nina created following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

Striking lung cancer response to self-administration of cannabidiol: A case report and literature review

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (


In spite of new drugs, lung cancer is associated with a very poor prognosis. While targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow-up. Thus, new drugs or re-evaluation of existing therapies used to treat other non-malignant diseases (drug repurposing) are still needed. While this research both in vitro and in vivo is being carried out, it is important to be attentive to patients where the disease responds to treatments not considered standard in clinical practice. We report here a patient with adenocarcinoma of the lung who, after declining chemotherapy and radiotherapy, presented with tumour response following self-administration of cannabidiol, a non-psychoactive compound present in Cannabis sativa. Prior work has shown that cannabidiol may have anti-neoplastic properties and enhance the immune response to cancer. The data presented here indicate that cannabidiol might have led to a striking response in a patient with lung cancer.


The quest to improve the prognosis of lung cancer has led to the development and evaluation of new drugs with mechanisms of action that differ from those of conventional chemotherapy drugs used for many years worldwide. Great effort is now being placed in developing and assessing the potential of targeted therapies and immunotherapy in lung cancer which are leading to improved clinical outcomes. 1 Thus, targeted therapy is replacing conventional chemotherapy as standard treatment for patients with targetable oncogenic drivers. 2 However, it has to be acknowledged that responses to these agents are still partial with tumours recurring during follow-up. In fact, due to tumours’ genetic heterogeneity, a complete response in lung cancer patients is very difficult to achieve. 2

The challenge to improve the outcome of patients with lung cancer is leading to the evaluation of alternative drugs which, alone or in combination, may lead to improved response and survival in patients with lung cancer. Therefore, further development of new drugs or even established therapies previously used to treat non-malignant diseases (drug repurposing) which could have shown an effect on lung cancer in vitro and/or in vivo are worth pursuing.

One possible example is cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa. CBD, which has been used in the management of several non-oncological pathologies, 3 could be a potential drug in the treatment of cancer. CBD has been shown to have anti-neoplastic effects in vitro and/or in vivo in lung cancer 4 –9 and other types of cancer. 10,11 However, although work is needed to better understand the mechanism/s of action of CBD both in vitro and in vivo, it is worth identifying any possible cases of patients with lung cancer whose disease responds to this drug. On this basis, we present here the case of a lung cancer patient whose tumour markedly responded to CBD.

In October 2016, an 81-year-old man with chronic obstructive pulmonary disease (COPD) presented to his general practitioner with a 3-week history of increasing breathlessness but no cough. A chest radiograph identified a shadow in the lower zone in the left lung, and subsequent CT scan confirmed the presence of a 2.5 × 2.5 cm mass in the lower left lung and multiple mediastinal lymph nodes ( Figure 1(a) and ( ​ (b)). b )). The patient underwent an endobronchial ultrasound guided biopsy of the paratracheal lymph nodes which revealed lung adenocarcinoma (T1c N3 M0). Tumour cells were strongly positive for CK7, thyroid transcription factor-1 (TTF-1) and with moderate focal expression of estrogen receptor (ER). They were negative for CK20, S100, PSA, CD56, synaptophysin and chromogranin. The tumour was negative for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) mutations.

CT scan image at diagnosis: (a) irregular rounded tumour seen in the periphery of left lower lobe, and (b) prominent multiple scattered mediastinal lymph nodes.

His previous medical history was COPD, diet controlled diabetes, and cancer of the prostate treated with radical prostatectomy in 2004 and in remission. He was not on regular medication and had no history of drug allergies. He was a retired salesman. There was no previous history of asbestos exposure. He was an ex-smoker (around 18 cigarettes daily for around 15 years) having stopped smoking 45 years ago. His ECOG performance status was 1. Physical examination was unremarkable.

The patient was offered chemotherapy and radiotherapy, but he declined as he was in his 80s and did not want any treatment that could adversely affect his quality of life. The decision was made to follow the patient up but without active treatment.

A CT scan in December 2016 showed that the lung mass had increased in size to 2.7 × 2.8 cm though the mediastinal and left hilar lymph nodes had not changed in size. The patient was offered treatment but again declined. A chest X-ray in July 2017 showed progressive changes in the left lower zone but no significant collapse or effusion evident. The patient had a further CT scan in November 2017 which revealed near total resolution of the left lower lobe mass with only a small area of residual spiculated soft tissue remaining (1.3 × 0.6 cm) and a significant reduction in size and number of mediastinal lymph nodes ( Figure 2(a) and ( ​ (b)). b )). The patient underwent another CT scan in January 2018 which showed stable appearances of the small residual opacity in the left lower lobe and mediastinal lymph nodes.

CT Scan image following the patient taking CBD: (a) marked regression of the left lower lobe mass leaving a small irregular residual linear band, and (b) striking regression of the mediastinal lymph nodes.

On further questioning, the patient stated that he had started taking CBD (“MyCBD”) oil 2% (200 mg CBD in 10 mL) from the beginning of September 2017. He took two drops (0.06 mL, 1.32 mg CBD) twice daily for a week and then nine drops (0.3 mL, 6 mg CBD) twice daily until the end of September. Following the November 2017 CT scan, the patient started taking nine drops twice daily but had to stop around a week later. The reason behind this was that the patient did not like the taste and caused him slight nausea. He was never physically sick. There were no other changes in the patient’s diet, medication or lifestyle from September 2017. Informed written consent was obtained from the patient.

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The data presented here may indicate that CBD led to a partial tumour response in a patient with histologically proven adenocarcinoma of the lung. Various possible mechanisms of action leading to this objective response might be postulated.

It has been described that CBD can act on tumour cells, directly or indirectly, through different pathways and that these effects might vary in different tumour cells. CBD acts as an inverse agonist for CB2 receptor and an antagonist for CB1 receptor. 12 However, CBD has low affinity to either CB1 or CB2 receptors. 9 In addition, CBD has anti-cancer effects acting as an agonist for the transient receptor potential vanilloid (TRPV) 1 and 2 leading to changes in intracellular Ca 2+ levels. 5,13

It is also reported that CBD can induce apoptosis in cancer cells via the production of reactive oxygen species (ROS), caspase activation 4,13,14 and activation of p53 dependent apoptotic pathways in cancer cells 14,15 and down-regulation of mammalian target of rapamycin (mTOR) and cyclin D1. 16 CBD can also upregulate TNF/TNFR1 and TRAIL/TRAIL-R2 signalling by modulation of both ligand and receptor levels followed by apoptosis. 14 Furthermore, CBD inhibits human umbilical vein endothelial cells (HUVEC) endothelial cells migration, invasion and sprouting in vitro, and angiogenesis in vivo through down-modulation of several angiogenesis-related molecules. 17

From the immunological point of view, CBD significantly inhibits the recruitment of tumour-associated macrophages (TAM) in primary tumour stroma and secondary lung metastases. 12 CBD enhanced the susceptibility of cancer cells to adhere to and subsequently be lysed by Lymphokine-Activated Killer (LAK) cells, with both effects being reversed by a neutralizing ICAM-1 antibody. 9

Based on these data, it is clear that several factors may have been involved in this patient’s response to CBD. However, although significantly lower potency in non-malignant cells has been described, 18 the effects of CBD on non-malignant cells has yet to be fully assessed.


In summary, the data presented here indicate that CBD may have had a role in the striking response in a patient with histologically proven adenocarcinoma of the lung as a result of self-administration of CBD oil for a month and in the absence of any other identifiable lifestyle, drug or dietary changes. Further work is needed both in vitro and in vivo to better evaluate the various mechanisms of action of CBD on malignant cells, and its potential application in the treatment of not only lung cancer but also other malignancies.


Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Ethical approval: Our institution does not require ethical approval for reporting individual cases or case series.

Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.

Informed consent: The patient described herein had given consent to the use of de-identified patient data for use in research and education. Written informed consent was obtained from the patient for his anonymized information to be published in this article.


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