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Best cbd oil for prostate cancer

CBD for Prostate Cancer [Does It Work?]

Prostate cancer is the second most prevalent form of cancer among American men, behind only skin cancer. According to the American Cancer Society, there are almost 250,000 new cases a year. Approximately 14% of men will fall victim to the condition during their lifetime.

Additionally, after lung cancer, prostate cancer is the second most fatal cancer among American men. Approximately 2.6% of those who suffer from the condition will die from it. In the U.S., an estimated 34,000 people die from the disease annually. Among men with local or regional prostate cancer, however, the outlook is more positive. 98% are still alive after ten years, while 96% are still alive after 15 years.

While there are many treatments for the condition, research suggests that CBD might kill prostate cancer cells. Though clinical trials do not yet verify this, it is a fascinating area of research.

This article will discuss CBD for prostate cancer and the relevant scientific research that exists on the matter. We’ll dive into available studies and attempt to find out whether CBD is a potential option for people living with prostate cancer. First, though, let’s discuss the condition itself.

What Is Prostate Cancer?

The prostate is a walnut-sized gland found in the reproductive system of men. It makes up most of the semen that carries sperm. The prostate resides below the bladder surrounding the urethra’s upper part. The urethra is the tube that carries urine from the bladder.

DID YOU KNOW? Men aged 50+ are at the greatest risk for prostate cancer. In most cases, victims will not notice symptoms until the cancer’s later stages.

Although doctors can treat prostate cancer if it remains localized, the condition is often deadly if it spreads through the body. While doctors are not 100% sure what causes prostate cancer, most agree that diet is a factor. Eating large amounts of fat from red meat may contribute.

It is known that meat cooked at high temperatures can produce cancer-causing substances. This may include substances that galvanize prostate cancer. Doctors also believe that high levels of testosterone increase prostate cancer risk, as does lack of exercise.

Traditional Prostate Cancer Treatments & Their Side Effects

Treatment for prostate cancer varies according to the stage the disease is in. For example, stage one prostate cancer could involve radiation therapy. In stage three, however, patients may require external radiation plus hormone therapy. Because the range of treatments varies, so does the range of side effects. Side effects of prostate cancer treatment can include:

  • Bowel complications
  • Urinary problems
  • Loss of fertility
  • Erectile dysfunction

The majority of treatments for localized prostate cancer work well. However, there are discussions regarding CBD as a natural alternative to prostate cancer treatment. There is little reliable research currently available. However, some studies show very intriguing signs regarding CBD’s action on cancerous cells in the prostate.

Can CBD Help Prostate Cancer? (Understanding the Research)

Cannabis has been championed as a means of easing the effects of chemotherapy for some time. However, new research suggests that it may also be capable of slowing – or altogether decreasing – the progression of cancerous cells.

In 2006, one of the first studies of its kind looked at the impact of THC on nine patients with glioblastoma multiforme – a type of brain tumor. The average life expectancy of these patients was 24 weeks. The study determined that THC inhibited the proliferation of tumor cells in vitro and decreased the prevalence of tumor cells in two patients when observed with immunostaining techniques.

Regarding cannabis and prostate cancer, positive results on animal models have led researchers to claim that preclinical evidence is sufficient to warrant clinical trials of cannabinoid medicines as anti-cancer treatments.

In the cited study, experts observe that prostate cancer cells have increased expression for cannabinoid receptors. In other words, it appears that cancerous prostate cells may be prone to the influence of pro-apoptotic activity in cannabinoids like CBD.

It is our conclusion that it would be of interest to conduct clinical trials involving medicinal cannabis or other cannabinoid agonists … in men with bone metastatic prostate cancer.

Indian Journal of Urology, 2012

Little is known regarding the specific physiological effects of cannabinoids on cancerous prostate cells. However, we know that cannabinoid activity in humans results from molecular interaction with the endocannabinoid system or ECS. The excessive number of receptors found on prostate cancer cells suggests that there is potentially a correlation between cancer cell proliferation and the presence of endocannabinoids.

Endocannabinoid deficiency is a condition wherein the body does not produce enough cannabinoids. Yet, the relationship of this condition with the development and progression of prostate cancer is, as of yet, unknown.

The Anti-Androgenic Effects of Cannabinoids

Androgens are male sex hormones (including testosterone) that cause the growth of prostate cells. One notable treatment for this form of cancer is known as ‘androgen deprivation therapy.’ As the name suggests, it deprives the body of androgens to slow the growth of cancerous cells.

At least one study suggests that cannabis possesses anti-androgenic properties. Anti-androgenic activity may impact the ability to grow muscle. The possible correlation between this unique cannabinoid property and prostate cancer progression is intriguing.

We look at the research …

While there are no current clinical studies on the use of CBD oil for prostate cancer, general research in the field is highly intriguing.

CBD: A Supplementary Natural Defense Against the Progression of Prostate Cancer Cells?

While marijuana also contains the intoxicating compound THC, CBD is entirely non-intoxicating. This means it poses no risk of causing a high. As for the specific use of CBD for prostate cancer, it is important to note there is minimal clinical data on the matter.

According to the NIH PubChem database, however, CBD possesses “anti-proliferative, anti-angiogenic and pro-apoptotic activity.” We know that the anti-proliferative effects of anandamide, an endocannabinoid in humans, work to prohibit metastatic prostate cancer cells. Based on this simple correlation, it is no stretch to surmise that CBD and its similar physiologic properties may produce similar effects.

Of course, the advancement of research is necessary to discuss CBD as a prostate cancer treatment realistically. While it is a fascinating area of research, much more information is required.

The ‘Best CBD Oil’ for Prostate Cancer? A Word of Warning

No company should claim to sell the ‘best CBD oil for prostate cancer.’ We’re not aware of any manufacturers making this claim. Nonetheless, it is always wise to use discretion when choosing any CBD product. Discrepancies in quality are common among various CBD products, so take the time to do plenty of research. Find a good, reputable brand that has quality customer reviews.

Also, we remind readers that CBD oil is not a treatment or a cure for prostate cancer. While research on the topic is largely positive, there is no clinical evidence that CBD works to slow or stop the spread of cancerous cells in the prostate.

Final Thoughts on CBD & Prostate Cancer

While limited, research on medical cannabis, CBD, and prostate cancer is positive. Researchers know, for example, that CBD possesses anti-proliferative and pro-apoptotic properties. These properties may work to slow or stop the spread of cancerous cells in the prostate.

Again, however, do not misinterpret initial research as clinical evidence. Much more clinical information is needed before doctors can consider CBD oil for prostate cancer a reliable treatment. As always, speak with a doctor before implementing CBD into a daily routine.

The anti-proliferative properties of CBD may have significance in terms of inhibiting the growth of prostate cancer cells.

Lastly, it is important to distinguish between treating prostate cancer and treating the symptoms that stem from cancer treatment. For example, nausea, pain, and low appetite are all common side effects of cancer treatment. We know that CBD and cannabis can be beneficial in easing these side effects. However, one should not confuse the easing of treatment side effects with actually treating the physiology of the disease itself.

CBD Oil for Cancer: Can Cannabis Oil Be Used as a Cure & Treatment?

It’s challenging to find a place that wouldn’t stock CBD today, at least in its traditional oil form. CBD oil has taken the United States by storm, driving the attention of doctors, researchers, and media outlets across the world. Universities are starting their research on the possibility of treating a variety of health conditions with CBD, including cancer.

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As CBD continues to change the public perception of cannabis, more people than ever are turning to CBD oil as a natural alternative for their ailments. In this article, we’re going to shed light on scientific research concerning the potential use of CBD oil for cancer and its symptoms.

We’ll also provide our list of recommended CBD oils that could potentially help individuals on their way to safe recovery.

CBD Oil for Cancer-related Symptoms

There is limited research into CBD’s potential as a treatment for cancer and its symptoms. The FDA refuses to acknowledge CBD oil as a treatment for cancer; there’s only one pharmaceutical containing cannabidiol — its name is Epidiolex. However, Epidiolex is reserved for epilepsy patients, not those struggling with cancer.

If you want to use CBD oil for cancer, make sure to make an appointment with a doctor first; doing so will give you a fuller image of how CBD oil could help your treatment.

While CBD isn’t a cure-all, it can surely help you ease several of its symptoms as well as some adverse reactions to chemotherapy and radiation.

Here’s what studies have found when it comes to using CBD oil for cancer.

Nausea

Researchers have proposed CBD as a natural resource to reduce nausea and vomiting due to how it interacts with the brain. Many patients regularly use cannabinoids to calm the uncomfortable sensation of nausea as an unwanted effect of chemotherapy, radiation, and anti-cancer medications. Moreover, CBD regulates serotonin levels, which can reduce the stimulation in the brain’s area responsible for vomiting.

Pain

In a 2015 study conducted by Care By Design, most patients who took CBD oil for pain and inflammation reported improvements in their symptoms. CBD acts on specific pathways in the brain that may reduce inflammation and block pain signals. Pain is one of the most troubling symptoms of cancer — and a side effect of chemotherapy — so these are very promising results for those suffering from cancer.

Fatigue and Sleep Disturbances

CBD is an adaptogen, meaning they can help the body maintain homeostasis within the body without negatively impacting its functioning as well as making any changes in the brain structure. Adaptogens are also classified as smart molecules because they can act exactly where they are needed to promote balance and strengthen regeneration processes, such as neurogenesis. When cancer patients suffer from a lack of sleep, CBD may help ease some of the stress and anxiety that are often associated with this condition. This can help the body regulate its sleep cycles.

CBD may also help target the specific processes in the body to provide it with enough energy and vitality, which can be useful for cancer patients after chemotherapy. On top of the above, it can also improve focus. Some scientists refer to CBD as “the boy scout molecule” because it always reaches the right target in any given situation.

Loss of Appetite

Although some individuals report appetite suppression after using CBD, it turns out it may have an opposite effect on others. When CBD reaches specific receptors in the brain, it can improve your appetite. And since the majority of cancer patients suffer from loss of appetite, this particular trait of CBD oil may come in handy when it comes to helping the body’s needs for nourishment, which the body needs throughout the disease and after radiation.

Can CBD Oil Help Cure Cancer?

There’s a lot of anecdotal evidence floating online from people claiming they have been cured of cancer by using cannabis. Scientific research performed on animals has shown that CBD can shrink tumors and stop them from spreading. For example, a research paper from 2011 showed that the stimulation of cannabinoid receptors through a mix of cannabinoids and fatty acids could potentially relieve prostate tumors.

Another study published in Plus One highlighted CBD’s anti-cancer properties to trigger a process of apoptosis — the death of cancerous cells — preventing tumor growth by reducing the number of certain proteins that are involved in the spread of malignant cells. The researchers concluded that they would recommend CBD as an anti-cancer agent due to its safety and lack of life-threatening side effects.

We’ve also visited the Cure your Own Cancer site, where patients provide their testimonials about their success in treating cancer with cannabis oil. The website was founded by a young activist Lincoln Horsley and it shares a lot of free information about cannabis, cancer, and how products like CBD oil can be used to support individuals on their way to recovery.

With all that said, using CBD oil for cancer isn’t an approved treatment because there haven’t been many human trials regarding this issue. Therefore, consumers must keep in mind that while anecdotal evidence about CBD oil and cancer is very optimistic, it must be scientifically investigated before being approved as a treatment method.

Best CBD Brands for Cancer Aid

The following compilation is a summary of CBD oils that we’ve selected after analyzing over 40 brands from local stores and online retailers. They have been evaluated according to the quality criteria such as hemp source, extraction methods, third-party testing, and customer service.

1. Royal CBD (Most Potent)

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Product Details

Potency 250 mg –2500 mg
Available Flavors Natural, Berry, Mint, Vanilla
CBD per serving 8.3 mg – 83.3 mg

Why Royal CBD is the Best CBD Oil for Cancer

My story with Royal CBD started about two years ago when we first read about them in one of our news briefs. They attracted us with the simplicity of their product selection, with only a few full-spectrum CBD oils available for sale. After two years, the company has grown by miles and expanded its line with capsules, gummies, and topicals — also adding a high-potency option to their oils.

Since then, Royal CBD oil has been our number one product.

Royal CBD oils come in four different potency options, including 250 mg, 500 mg, 1000 mg, and 2500 mg. You can choose from flavors like Mint, Berry, and Vanilla, save for the highest strengths, which only comes in the unflavored version. These are full-spectrum products, meaning they were made using the whole plant and contain all the non-psychoactive cannabinoids and terpenes originally found in hemp. I’ve noticed the best results when it comes to nausea and pain relief using the 2500 mg bottle. The oil has also helped calm my anxiety and improved sleep.

Note: Royal CBD is only available online; you won’t find it in any local store, although their online shop offers great discounts and a loyalty program that lets you save money on their products.

  • Sourced from locally grown organic hemp
  • Extracted with supercritical CO2
  • Contains full-spectrum CBD
  • Available in 4 potencies and flavors
  • Up to 2500 mg of CBD per bottle
  • Only available online

2. Gold Bee (Best Flavor)

Product Details

Potency 250 mg –1200 mg
Available Flavors Natural, Honey
CBD per serving 8.3 mg – 83.3 mg

About Gold Bee

Gold Bee is a Nevada-rooted brand that focuses on making honey-flavored CBD extracts. The company has developed its own blend of high-CBD strains in partnership with local growers from Colorado. These plants are grown from non-GMO seeds in healthy soils and without growth boosters or pesticides.

Aside from the premium quality of ingredients, I believe this brand deserves much appreciation for how they mix CBD with honey. The flavor is surprisingly natural and masks the earthy hemp aftertaste that you get from full-spectrum CBD oil.

About the effects, I noticed similar results with my anxiety and pain to what I got from Royal CBD oil, but due to the lack of high-potency oil in its selection, I’ve decided to give the guys at Gold Bee second place.

However, if low-to-moderate doses of CBD work for you, this is one of the best brands to purchase CBD oil from.

  • Made from US-grown organic hemp
  • Infused with full-spectrum CBD
  • Up to 33 mg CBD/mL
  • Decent potency range for beginners
  • Third-party tested for potency and purity
  • Delicious honey flavor
  • No high-potency oils in their collection
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3. CBDPure (Best Transparency)

Product Details

Potency 100 mg –1000 mg
Available Flavors None
CBD per serving 3.3 mg – 33 mg/mL

About CBDPure

CBDPure specializes in making mostly low-potency CBD oil. Recently, the brand has added a 1000 mg potency to their collection, which we simply couldn’t miss.

One interesting thing about CBDPure is that its low-potency oils work better than some high-potency products I’ve tried so far. For me, CBDPure is a textbook example of how to make top-of-the -shelf full-spectrum extracts. The effects were very similar to what I’ve experienced with the other two companies in this ranking.

CBDPure is my third-best pick on this list because both Royal CBD and Gold Bee offer a better price/quality ratio.

  • Made from organic Colorado-grown hemp
  • Extracted with supercritical CO2
  • Lab-tested for CBD content and purity
  • Contains full-spectrum CBD
  • 90-day return policy
  • Only two types of product available
  • Low strength
  • More expensive than the competition

4. Hemp Bombs (Best CBD Isolate)

Product Details

Potency 125 mg – 4000 mg
Available Flavors Natural, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
CBD per serving 4 – 133 mg/mL

About Hemp Bombs

Hemp Bombs is an American manufacturer that produces CBD oil made from 99% pure isolate. The company offers an extensive range of CBD extracts, offering up to 4000 mg of total CBD. This CBD oil is an excellent choice for cancer patients who, for some reason, want to avoid any THC in their oil. Full-spectrum products contain 0.3% THC or less, which isn’t enough to get anyone high, but CBD isolate is 100% THC-free.

CBD isolate is also odorless and flavorless, so it’s a good alternative for those who have problems with holding full-spectrum extracts in their mouth. That being said, there’s no synergy from other cannabinoids and terpenes, so Hemp Bombs may not be the best choice for those looking for the entourage effect in cannabis.

  • Sourced from organic hemp
  • Extracted with supercritical CO2
  • THC-free
  • Available as broad-spectrum or isolate
  • Third-party tested for CBD and purity
  • Up to 4000 mg of total CBD
  • 5 strengths to choose from
  • Infused with synthetic flavorings
  • No synergy from other cannabinoids and terpenes
  • Most people don’t need such high-potency oils in their routine

5. CBDistillery (Best Price)

Product Details

Potency 250 mg – 5000 mg
Available Flavors None
Potency 8.3 – 166 mg/mL

About CBDistillery

CBDistillery is one of the largest CBD companies in North America. The brand was launched by a group of Colorado citizens based on a mutual goal to supply consumers with affordable products that still match the highest quality standards. CBDistillery’s products are available in an extremely wide range of potencies, from 250 mg to a whopping 5000 mg of CBD per bottle. The highest potency contains 166 mg of CBD in each milliliter, which is enough to get yourself a few month’s worths of supplies.

You can also choose which type of CBD extract you want in your oil because CBDistillery offers both full-spectrum and broad-spectrum extracts (pure CBD oil). In the broad-spectrum variant, THC has been completely removed after initial filtration, but the other cannabinoids and terpenes from hemp have been preserved.

CBDistillery has scored the last place in your compilation of the best CBD oils for cancer due to their hemp sourcing practices — the plants used by the company are non-GMO but not certified organic.

  • Available as full-spectrum or broad-spectrum CBD
  • Extracted with CO2
  • 5 strengths to choose from
  • Up to 166.6 mg of CBD per bottle
  • Third-party tested for potency and purity
  • Very affordable
  • Their hemp isn’t organic
  • No flavored options

What is CBD?

CBD is one of over 100 compounds in cannabis plants, which are categorized as cannabinoids. Unlike its psychoactive cousin THC, CBD can’t make you feel high. However, it still offers a plethora of benefits for our health.

It turns out that all mammals have an endocannabinoid system (discovered in the 1990s), which is a prime self-regulatory network composed of cannabinoid receptors and neurotransmitters known as endocannabinoids. Endocannabinoids are chemical messengers that are released to maintain homeostasis in the body, which is a state of equilibrium between all bodily functions, such as pain signaling, appetite, sleep cycles, immune function, emotional processing, and more.

CBD acts as a modulator, meaning it signals the endocannabinoid system to produce and maintain more of its native cannabinoids to help them effectively maintain the balance within the body.

CBD can also help the endocannabinoid system regain its proper functioning when homeostasis has been disrupted. Through the said signaling, it can promote the formation of healthy cells in the body while turning on the process of apoptosis — the destruction of malignant cells.

People use CBD for a wide range of health problems, from common anxiety to inflammatory conditions and severe chronic diseases, such as osteoarthritis, epilepsy, Autism Spectrum Disorders, and cancer.

What is CBD Oil?

CBD oil is a liquid extract that contains high concentrations of CBD. It is made using hemp flowers, the resinous part of the plant. After initial extraction, CBD oil usually undergoes filtration to dump the redundant plant material and suspend the extract in a food-grade carrier oil, such as hemp seed oil or MCT oil.

CBD oil comes in glass bottles with a dropper attached for easier and precise dosing. To take CBD oil, you need to use the dropper to measure out the dose and place the oil beneath your tongue, allowing it to sit there for about one minute to let it absorb through special membranes in the mouth. You can swish it around the mouth to increase the surface area and increase the oil’s bioavailability.

Is CBD Oil Legal?

CBD can be produced from hemp and marijuana, so it’s understandable that you may have questions about its legality.

Marijuana-derived CBD oil will contain a considerable amount of THC, which crosses the legal 0.3% barrier. Such products can get the user high and are legal only in states that legalized recreational marijuana use. In states with a medical marijuana program, you can apply for a medical marijuana card to purchase marijuana-derived CBD oil from one of the state-licensed dispensaries.

Hemp is legal on the federal level because it contains up to 0.3% THC, which can do anything but produce a psychoactive buzz. In 2018, hemp was removed from the list of controlled substances. Hemp-derived CBD oil can be found over the counter in pharmacies, dispensaries, fitness studios, local health stores, and online. It’s a plant-based supplement, so you don’t need a prescription for it.

Final Thoughts on Using CBD Oil for Cancer

Researchers agree that cancer patients could benefit from CBD oil to some extent, but there is still much we don’t know about the exact mechanism behind its anti-cancer potential. Therefore, it’s too early to draw any conclusions.

Fortunately, CBD has garnered much attention from the medical community lately, and scientists are willing to further investigate its effects on cancer, its symptoms, and the side effects of chemotherapy. For instance, the Spanish Observatory on Medical Cannabis is aggressively researching cancer treatment with cannabis extracts, regularly posting their findings on its website.

If you want to try CBD oil to support your well-being during your cancer treatment and ease some of the uncomfortable side effects of chemotherapy, consult your doctor about it, and above all, always buy your CBD oil from a reputable source that can provide premium-quality ingredients proven by lab-testing reports.

Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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Using cannabis in prostate cancer patients

In our hospital’s daily practice we notice the popular use of cannabis oil in prostate cancer (PCa) patients. As a nursing specialist for urology, I have even met patients who are so convinced of the curative benefits of cannabis oil in treating prostate cancer that they replace standard treatment with the use of cannabis oil.

These patients include those who have localised prostate cancer where active surveillance is followed, those with biochemical recurrence after treatment, and patients with metastatic PCa. I have always wondered whether cannabis oil could indeed be a cure for prostate cancer. Unfortunately, I do not see in practice the desired beneficial effect and the PSA values continue to rise. To find some answers, I did a search in scientific literature.

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Cannabis, a very easy plant to grow, has been used for centuries for its medicinal properties. The oldest known document about cannabis use originates from the Chinese emperor Shen Nung in 2727 B.C. It suggested that cannabis has a neuron-protective effect. The Egyptians used cannabis to treat glaucoma and as an anti-inflammatory agent (inflammation of the eyes, fever). Cannabis was even used in obstetrics (mixed with honey) and the mixture was applied in the vagina to “cool” the uterus. In the Old Testament, there is also an account of God instructing Moses to make a holy anointing olive oil-based “Kaneh Bosm.”

Cannabis contains more than 400 chemical components 80 of which contain cannabinoid components and 200 non-cannabinoids components. For medical purposes, cannabinoid substances such as THC (Delta-9-tertrahydrocannabinol), CBD (cannabidiol) and non-cannabinoid substances such as terpenoids and flavonoids are relevant.

Medicinal cannabis must be distinguished from recreational cannabis which is used to achieve a psychotomimetic state of ‘high’. Cannabis strains used for recreational purposes contain a higher THC and lower CBD ratio than cannabis for medicinal use. Usually two cannabis plants are used: cannabis sativa which has a higher THC concentration and cannabis indica which has a higher CBD concentrate. The flavonoids are known for their antioxidant and anti-inflammatory effects. The terpenoids are resins (oil) with a strong odour.

In the 1990s, the endocannabinoid system (ESC) of the body was discovered by Raphael Mechoulam, an Israeli professor of medical chemistry. The endocannabinoid system, a central regulatory system, is the body’s largest receptor system and is important to maintain the homeostasis of the body.

Human beings produce their own cannabinoids (endocannabinoids) according to need and are not stored in the body. Like endorphins, the human body produces endocannabinoids in response to activities such as physical exercise (the high of runners might be due to endocannabinoids, not endorphins!).

Cannabinoid receptor type 1 (CB1) is mainly found in the brain, and also in the lungs, the reproductive organs, etc. Cannabinoid receptor type 2 (CB2) is usually located in the immune system and in the bones. THC mainly works on CB1 receptors, CBD on CB2 receptors.

In vitro studies with THC have shown that cannabinoids affect migration, angiogenesis and apoptosis (programmed cell death) of cancer cells, but each type of cancer appears to respond differently to the effect of exogenous cannabinoids. Many types of cancer cells have a higher concentration of CB1 and CB2 receptors.

Use of cannabis in cancer

– Pain: Cannabinoids have been used for centuries to lessen pain. Historical texts and old pharmacopoeia noted the use of cannabis for menstrual cramps, pain during childbirth, and headaches. Studies have shown that the cannabinoids have no effect on acute pain and post- operative pain. Two placebo-controlled studies with a cannabis extract showed modest benefits when using cannabinoids in addition to opioids and other adjuvant pain-killers in cancer patients with chronic pain. However, the effect of cannabinoids in chronic neuropathic pain was clearly demonstrated in 29 randomized studies.

– Nausea and vomiting: An initial study in 1975 showed a beneficial effect of THC on nausea induced by chemotherapy. Subsequently, two systematic reviews showed benefits of cannabinoids in nausea and vomiting due to chemotherapy, but most studies were observational or uncontrolled.

– Stimulation of appetite: Cannabinoids seem to have only a modest effect in cancer patients with cachexia. More promising results were seen in studies in the population without cancer.

– Pre-clinical studies (in vitro = cells in laboratory and in vivo = in mouse model) have shown the antiproliferative, anti-metastatic, anti-angiogenic and pro-apoptotic effects of cannabinoids in various malignancies (lung, glioma, thyroid, lymphoma, skin, pancreas, endometrium, breast and prostate). Even if an identified substance in vitro / in vivo appears to have a beneficial effect on a disease, it is important to realise that only one in 5,000-500,000 substances obtain a registration and becomes available to the patient (after 10-16 years of different study phases). Cannabis has never been clinically studied as a treatment for malignancy.

On the Internet, patients can get a lot of information about the curative effect of cannabis oil on prostate cancer but this information extrapolate the results of pre-clinical work to possible effects in people without any factual evidence. I often see patients in the doctor’s office showing me a website where it has been proven that cannabis oil can cure prostate cancer, which is obviously their own interpretation. In my view this can be a misleading message even though the website does not explicitly provide false information. The website [See figure below] shows information which is based on a study published in the British Journal of Cancer. This is correct, but the website “neglects” to mention that this is a publication of an in vitro study. The patient might not even know what an in vitro study is and is not aware that there are no studies on humans yet to prove this.

A challenge for the caregiver can be that the patient is convinced that we as healthcare practitioners work together with the pharmacists, and that we do not wish to carry out clinical trials (unfortunately, I hear that very often). We can hardly persuade patients that this is not true.

It is also important that we inform the patient about the possible interactions of cannabis oil with certain regular medications such as Coumarin (this blood thinner interacts with cannabis oil, leading to an increase of the INR and a greater risk of bleeding!). There are different types of cannabis oil available, such as CBD and THC oils with different concentrations which makes it difficult for patients to make a choice.

Conclusions:
• There is no proof of cannabis oil as cure for prostate cancer;
• It is important not to be prejudiced or judgmental against patients who use cannabis oil;
• Listening to the patient’s view can be helpful since the patient often confides to the nurse rather than to their physicians;
• Avoid persuading patients not to use cannabis oil, but try to convince them of the need to follow a regular treatment combined with cannabis oil;
and
• Consider adverse interactions between cannabis oil and certain medications and inform your patient about these.

References

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  • De Petrocellis L. et al. Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo:pro-apoptotic effects and underlying mechanisms. Br J Pharmacol. 2013 Jan; 168(1): 79–102.
  • Guindon, J. Hohmann, A.J. The Endocannabinoid System and Cancer.: Therapeutic Implication. British Journal of Pharmacology. 163, 14447-1463 (2011) – Johnson J.R et al. Multicenter, dubbel blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety and tolerability of THC: CBD extract and THC extract in patients with intractable cancerrelated pain. J.Pain Symptom Manage 2010;39:167-79.
  • Machado Rocha F.C. et al. Therapeutic use of Cannabis Sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis. Eur. J. Cancer Care 2008;17:431-43.
  • Olea-Herrero N. et al. Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2. British Journal of Cancer volume 101, pages 940–950 (15 September 2009).
  • Portenoy R.K et al. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded dose trial. J. Pain 2012;13:438-49.
  • Ramos J.A. et al. The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. Indian J Urol. 2012 Jan-Mar; 28(1): 9–14.
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Corinne Tillier, Nurse Practitioner Urology, Antoni van Leeuwenhoek Hospital, Amsterdam (NL), [email protected]