8 Medical Conditions That CBD Can Help Treat
It seems like everywhere you look, cannabidiol, better known as CBD, is being touted as a cure for, well, anything that might ail you. At last check, you can find CBD in hundreds of products meant to relieve all manner of pain and anxiety, and in lifestyle-enhancing products like sports-recovery balms, personal lubricants, sleeping aids, and energy boosters that might keep you up all night (yep, take your pick!).
What Is Cannabidiol (CBD) and Where Is It Found?
But first, what is CBD? Cannabidiol is a nonpsychoactive compound found in both cannabis and hemp plants, which are different varieties of the same plant species. Cannabis plants are often grown in order to cultivate tetrahydrocannabinol (THC), which is the component in marijuana that is responsible for the “high” feeling in people who smoke or ingest it. Many hemp plants, on the other hand, have had the THC largely bred out of them, according to a report published in November 2016 in Critical Reviews in Plant Sciences. These plants are grown for a variety of products, including textiles, insulation, food, paper, supplements, and skin-care items.
While headlines may lead you to believe that CBD — sold in oils, edibles, tinctures, creams, capsules, and more — is a cure-all, there are really just a handful of conditions that scientific studies suggest it can treat, according to a report published in 2018 by the World Health Organization. It’s important to know that CBD is treated by the Food and Drug Administration (FDA) the same way as dietary supplements — that is, like supplements, CBD products can go to market without scientific evidence that they actually work. It’s a “buyer beware” situation.
Can CBD Help With Post-Traumatic Stress Disorder?
What Conditions Is CBD Used For?
Here’s a look at what a handful of scientific studies have found in recent years concerning CBD’s medical usefulness, including some diseases and ailments for which the FDA has approved CBD products.
- Pain When CBD reaches a family of receptors, or cells that receive stimuli, called vanilloid receptors, the interaction results in lower inflammation and levels and pain perception, according to a study published in Current Neuropharmacology. And a study published in July 2016 in the European Journal of Pain found that CBD could help people with arthritis manage their pain. The animal study looked at whether using a CBD gel transdermally (on the skin) would reduce inflammation and signs of pain, and researchers concluded that the topical product did offer relief from pain-related behaviors without evidence of side effects.
- Anxiety and depression Hundreds of studies have looked at how cannabidiol might be used to treat various neuropsychiatric disorders. One of the most recent, published in October 2015 in Neurotherapeutics, concluded that topical CBD has “considerable potential as treatment for multiple anxiety disorders.” What’s more, a study review published in September 2015 in the Journal of the American Society for Experimental NeuroTherapeutics found that “preclinical evidence strongly supports CBD as a treatment for anxiety disorders,” including PTSD, generalized anxiety disorders, obsessive-compulsive disorder, and seasonal affective disorder.
- Epilepsy Anecdotal reports about CBD’s use as a treatment for epilepsy have been around for decades, and a handful of rigorous scientific studies seem to support these claims. One, published in May 2018 in the New England Journal of Medicine, showed CBD to be effective at reducing the number of seizures in people with a form of epilepsy called Lennox–Gastaut syndrome (LGS). And in 2018, the FDA approved an oral CBD formulation for LGS and another type of epilepsy called Dravet syndrome.
- Symptoms related to cancer treatment The focus on CBD for cancer treatment has been for its use in reducing the nausea and vomiting that often accompany chemotherapy and radiation treatments. Two cannabinoid drugs have been approved by the FDA to combat those side effects: Marinol (dronabinol) and Cesamet (nabilone). More recently, researchers have discovered CBD may slow the growth of cancer cells, according to the American Cancer Society.
- Acne and other skin issues A study published in July 2014 in the Journal of Clinical Investigation suggested topical CBD can be a potent antiacne agent, likely because of its anti-inflammatory properties. And a study published in July 2017 in the Journal of the American Academy of Dermatology found CBD (and THC) useful for reducing the itch and inflammation associated with eczema and psoriasis.
- High blood pressure Researchers in England studied the effects of CBD on a small group of healthy men ages 19 to 29 — all nonsmokers who had never used cannabis — and discovered a single dose of CBD reduced resting blood pressure by 6 millimeters of mercury (mmHg), which may ultimately also reduce the risk of stroke. The study, published in July 2017 in JCI Insight, concluded that the response may be due to CBD’s anxiolytic (anxiety-reducing) and analgesic (pain-reducing) effects.
- Addiction As ironic as it sounds, CBD — which technically is classified as a Schedule I substance by the Drug Enforcement Administration and as such is currently illegal in nearly half the United States — has shown a lot of promise in fighting addiction to everything from opioids and cocaine to alcohol and tobacco. In addition, a number of preclinical studies, including a study published in June 2017 in Cannabis and Cannabinoid Research, suggest CBD might be useful as a pain therapy in place of opioids.
- Diabetes A number of studies, including one published in February 2012 in the American Journal of Pathology, have suggested that CBD could play a role in improving outcomes for people with diabetes. Observational studies have shown that people who use marijuana have lower fasting insulin levels and measures of insulin resistance.
Is CBD Right for You, and What Are the Possible Side Effects?
If you’re suffering from any of the ailments or diseases on this list and are curious to see if CBD could help, you should also know about the side effects that some people experience when using CBD products. The most common are dizziness, dry mouth, mood changes, gastrointestinal issues — including nausea — and fatigue. And since research has shown that CBD can interact with a variety of medications, including warfarin (a blood thinner) and clobazam (used to treat epilepsy), it’s essential to discuss your use of CBD-containing products with your physician or other healthcare provider.
How Do You Know What’s in CBD Products?
The next challenge is finding products that are accurately labeled. According to research published in November 2017 in the Journal of the American Medical Association, many CBD products do not contain the amount of CBD their labels claim. The research, conducted at the University of Pennsylvania Perelman School of Medicine, involved testing 84 CBD products to see if they contained the amount of CBD listed. The researchers found 70 percent of CBD products are mislabeled, and “26 percent contained less CBD than labeled, which could negate any potential clinical response.”
Like any other product, from aspirin to zinc oxide, CBD is not for everyone. And even though it’s “natural,” it’s not necessarily safe, especially for people who are taking other medications. If you decide to try CBD products, make sure you know where the products are sourced from, how they’re manufactured, and how they’re meant to be used.
What Is CBD Oil?
This cannabis extract may help treat nerve pain, anxiety, and epilepsy
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman’s World, and Natural Health.
Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.
Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.
Cannabidiol (CBD) oil is an extract from hemp plants called Cannabis indica and Cannabis sativa . You might be more familiar with cannabis plants because they are grown for marijuana. However, CBD is not the same thing as marijuana.
CBD oil contains CBD that’s mixed with a base (carrier) oil, like coconut oil or hemp seed oil. These are called tinctures. You can get tinctures in different concentrations. The oil can also be put into capsules, gummies, and sprays.
People who support using CBD oil say that it can treat pain and anxiety; can help stimulate appetite and may help manage some types of seizures.
This article goes over what CBD is used for, the possible side effects, and what you should look for if you choose to buy CBD.
CBD vs. Marijuana
CBD is one component (called a cannabinoid ) that’s found in a hemp plant. Marijuana is a separate plant but it’s from the same species that hemp belongs to. Marijuana has CBD and hundreds of other compounds in it.
The main difference between hemp plants and marijuana plants is how much of a compound called tetrahydrocannabinol (THC) is in them. Hemp is grown to have less than 0.3% THC, while marijuana has more.
THC is what’s responsible for the psychoactive effects of cannabis—in other words, it’s what makes you feel “high.”
CBD oil generally does not have THC in it; however, a very small (trace) amount might be in products sold in certain states.
What Is CBD Oil Used For?
We’re not sure exactly how CBD works. Unlike THC, CBD doesn’t have a strong connection with the molecules in the brain that THC binds to create psychoactive effects. These are called cannabinoid receptors.
Instead, CBD works on other receptors, like the opioid receptors that help control pain. It also affects glycine receptors that control a brain chemical called serotonin which helps control your mood.
People that support the use of CBD claim that CBD oil can treat a variety of health problems, including:
- Chronic pain
- Drug use and withdrawal
- High blood pressure
- Muscle spasms
- Poor appetite
As CBD has gained popularity, researchers have been trying to study it more. Still, there has not been a lot of clinical research to look for evidence in support of these health claims.
CBD is not a safe option for everyone. Talk to your healthcare provider if you want to try it for managing a health condition.
A 2015 review of research that was published in the journal Neurotherapeutics suggested that CBD might help treat anxiety disorders.
The study authors reported that CBD had previously shown powerful anxiety-relieving effects in animal research—and the results were kind of surprising.
In most of the studies, lower doses of CBD (10 milligrams per kilogram, mg/kg, or less) improved some symptoms of anxiety, while higher doses (100 mg/kg or more) had almost no effect.
The way that CBD acts in the brain could explain why this happens. In low doses, CBD might act the same as the surrounding molecules that normally bind to the receptor that “turns up” their signaling.
However, at higher doses, too much activity at this receptor site could produce the opposite effect.
There have not been many trials to look at CBD’s anxiety-relieving effects in humans. However, one was a 2019 study published in the Brazilian Journal of Psychiatry.
For the study, 57 men took either CBD oil or a sugar pill with no CBD in it (placebo) before a public-speaking event.
The researchers assessed the participants’ anxiety levels using measures like blood pressure and heart rate. The researchers also used a reliable test for mood states called the Visual Analog Mood Scale (VAMS).
The men who took 300 mg of CBD oil reported less anxiety than the men who were given a placebo; however, the men who took 100 mg or 600 mg of CBD oil did not experience the same effects.
CBD oil might help people with substance use disorder, according to a 2015 review published in the journal Substance Abuse.
The review looked at the findings from 14 published studies. Nine of the studies looked at the effects of CBD on animals, and five studies looked at the effects on humans.
The researchers reported that CBD showed promise for treating people with opioid, cocaine, or psychostimulant use disorders.
However, the effects of CBD were quite different depending on the substance. For example, CBD without THC did not decrease withdrawal symptoms related to opioid use.
On the other hand, it did reduce drug-seeking behaviors in people using cocaine, methamphetamine, and other similar drugs.
Some experts suggest that CBD could help treat cannabis and nicotine dependence, but more research is needed to provide this theory.
High Blood Pressure
A 2017 study found that CBD oil may reduce the risk of heart disease because it can lower high blood pressure in some people.
For the study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. The men who took CBD had lower blood pressure before and after experiencing stressors like exercise or extreme cold.
The study also looked at the amount of blood remaining in the heart after a heartbeat (stroke volume).
The stroke volume in the men who took CBD was lower than in was in the placebo group, meaning their hearts were pumping more efficiently.
The study suggested that CBD oil could be a complementary therapy for people with high blood pressure that is affected by stress and anxiety.
However, there is no evidence that CBD oil can treat high blood pressure on its own or prevent it in people at risk. While stress can complicate high blood pressure, it does not cause it.
In June 2018, the U.S. Food and Drug Administration (FDA) approved a CBD oral solution called Epidiolex.
Epidiolex is used to treat two rare forms of epilepsy in children under the age of 2: Dravet syndrome and Lennox-Gastaut syndrome. These are very rare genetic disorders that cause lifelong seizures starting in the first year of life.
Other than for these two disorders, CBD’s effectiveness for treating seizures is not known. Even with Epidiolex, it’s not clear if the anti-seizure effects are from CBD or another factor.
However, there is some evidence that CBD interacts with seizure medicines like Onfi (clobazam) and raises their concentration in the blood. That said, more research is needed to understand the link.
Possible Side Effects
Clinical research has shown that CBD oil can cause side effects. The specific side effects a person has and how bad they are varies from one person to the next and from one type of CBD to another.
Some common side effects people report from using CBD include:
- Changes in appetite
- Changes in mood
- Dry mouth
CBD oil may also increase liver enzymes, which is a marker of liver inflammation.
People with liver disease should talk to their healthcare provider before taking CBD oil. They may need to have their liver enzymes checked regularly if they are using CBD.
Can You Use CBD If You’re Pregnant?
You should not use CBD oil if you’re pregnant or breastfeeding. Even though the effects of CBD are not fully understood, it does pass through the placenta.
The American Academy of Pediatrics (AAP) further states that pregnant people should not use marijuana because of the potential risks to a developing fetus.
Do not drive or use heavy machinery when taking CBD oil—especially when you first start using it or switch to a new brand. Remember that some products do contain THC, even in small amounts.
CBD oil can interact with medications, including many that are used to treat epilepsy. One of the reasons for this has to do with how your body breaks down (metabolizes) drugs.
Cytochrome P450 (CYP450) is an enzyme your body uses to break down some drugs. CBD oil can block CYP450. That means that taking CBD oil with these drugs could make them have a stronger effect than you need or make them not work at all.
Drugs that could potentially interact with CBD include:
- Anti-arrhythmia drugs like quinidine
- Anticonvulsants like Tegretol (carbamazepine) and Trileptal (oxcarbazepine)
- Antifungal drugs like Nizoral (ketoconazole) and Vfend (voriconazole)
- Antipsychotic drugs like Orap (pimozide)
- Atypical antidepressants like Remeron (mirtazapine)
- Benzodiazepine sedatives like Klonopin (clonazepam) and Halcion (triazolam)
- Immune-suppressive drugs like Sandimmune (cyclosporine)
- Macrolide antibiotics like clarithromycin and telithromycin
- Migraine medicine like Ergomar (ergotamine)
- Opioid painkillers like Duragesic (fentanyl) and alfentanil
- Rifampin-based drugs used to treat tuberculosis
Always tell your healthcare provider and pharmacist about all the medicines you take, including prescription, over-the-counter (OTC), herbal, or recreational drugs.
The interactions between these medications and CBD are often mild and you might not have to change your treatment.
However, in some cases, you might have to change medications or space out your doses to avoid a reaction. That said, never change or stop medication without talking to your provider.
Dosage and Preparation
There are no guidelines for using CBD oil. Each product works a bit differently, depending on the form.
For example, putting the oil under your tongue can produce effects more quickly than swallowing a capsule that needs to be digested.
Here are a few ways that you can take CBD oil:
- Placing one or more drops under your tongue and holding it there for 30 to 60 seconds without swallowing. You can also use a spray that is spritz in your mouth/under your tongue.
- Taking a capsule or chewing a gummy
There’s no “correct” dose of CBD oil. How much you take and the form you choose will depend on your needs and what you hope to get for effects. The average dose range is from 5 mg to 25 mg.
Most oils come in 30-milliliter (mL) bottles and include a dropper cap to help you measure.
That said, it’s hard to figure out the exact amount of CBD per milliliter of oil. Some tinctures have concentrations of 1,500 mg per 30 mL, while others have 3,000 mg per mL or more.
How to Calculate CBD Dose
To determine an exact dose of CBD, remember that each drop of oil equals 0.05 mL of fluid. This means that a 30-mL bottle of CBD oil will have about 600 drops in it.
If the concentration of the tincture is 1,500 mg per mL, one drop would have 2.5 mg of CBD in it. The math to figure that out looks like this: 1,500 mg ÷ 600 drops = 2.5 mg
What to Look For
CBD oil comes in different forms: isolates, broad-spectrum, and full-spectrum.
- Isolates contain only CBD
- Broad-spectrum oils nearly all of the components of the plan (e.g., proteins, flavonoids, terpenes, and chlorophyll), but does not have THC oils have all the compounds including THC (up to 0.3%)
Alternative medicine practitioners believe that the compounds provide more health benefits, but the is a lack of evidence to support these claims.
Remember that CBD oils are unregulated. There’s no guarantee that a product is what it claims to be on its packaging. You also can’t know for sure that it’s safe and effective.
A 2017 study reported that only 31% of CBD products sold online were correctly labeled. Most had less CBD in them than was advertised, and 21% had significant amounts of THC.
If you are interested in buying CBD products, here are a few tips to keep in mind:
- Buy American: Domestically produced CBD oil might be a safer option than those that have been imported.
- Go organic: Brands certified organic by the U.S. Department of Agriculture (USDA) are less likely to expose you to pesticides and other harmful chemicals.
- Read the product label: Even if you choose a full-spectrum oil, don’t assume that every ingredient on the product label is natural. CBD products can also have preservatives, flavorings, or thinning agents in them. If you don’t recognize an ingredient, ask the dispenser what it is or check online.
Hemp plants can be grown for different purposes. Some species are made for marijuana but others are used to make CBD products.
Unlike marijuana, CBD oil does not “get you high.” Instead, it may help relieve stress, anxiety, drug withdrawals, and nerve pain.
While there are many claims about the health benefits of using CBD oil, the evidence is lacking. A lot of studies were done with animals, not humans.
If you want to try CBD oil, you should learn about the different dosages and preparations first.
You should also know that the products are not regulated, which means you can’t know for sure that a product will work and be safe.
Before you use CBD oil, talk to your provider. If you take certain medications or have a health condition, you may not be able to use these products.
Frequently Asked Questions
It would be hard to overdose on CBD oil. Research has shown that human tolerance for CBD is very high. One study reported the toxic dose would be about 20,000 mg taken at one time.
It depends on where you live, the type of product, how it was sourced (e.g., is it from hemp or marijuana), and its intended purpose (medical or recreational). In many states, you must be 18 or 21 to buy CBD oil. Check your state’s laws.
Not necessarily. While the names are sometimes used interchangeably, hemp oil can also refer to hemp seed oil, which is used for cooking, food production, and skincare products.
CBD oil is made from the leaves, stems, buds, and flowers of the Cannabis indica or Cannabis sativa plant. It should contain less than 0.3% THC.
Hemp oil is made from the seeds of Cannabis sativa and does not have TCH in it.