Cbd oil for arthritis john hopkins
Medical Cannabis: John Hopkins Study Shows That Medical Cannabis Can Help With Insomnia, Pain and Stress
Medical Cannabis : A new study involving nearly 1,300 individuals by John Hopkins University School of Medicine has shown that medical cannabis can help individuals having issues with insomnia, pain and stress.
The study lead by Dr Ryan Vandrey, an Associate Professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine in Baltimore is published in the journal: Cannabis and Cannabinoid Research.
A research involving nearly 1,300 people with chronic health conditions, found that those using “medicinal cannabis” reported less pain, better sleep and reduced anxiety.
These users also tended to use fewer prescription medications and were less likely to have been to the hospital recently.
Numerous states in America have made marijuana legal for medical or recreational use, and studies have looked at whether those laws are linked to increased marijuana use, car accidents or emergency room visits.
However there is little research that has examined the impact of legalization on the individuals who use medicinal cannabis.
The research findings that cannabis users felt better than nonusers is not necessarily surprising, according to Dr Vandrey. But it’s important to demonstrate it in a study, he stressed.
The study results do not prove, however, that medicinal cannabis is effective. It’s also unclear whether certain products were linked to particular benefits.
Medicinal cannabis included not only formulations of THC: the chemical behind marijuana’s “high” but also cannabidiol, or CBD, which does not create a high. Fifty-eight percent of users were taking “CBD-dominant” oils, tinctures and other products.
Cannabidiol has exploded in popularity across the United States in recent years, and is marketed in everything from oils and capsules to cookies and coffee. The purported benefits are also wide-ranging, and include relief from chronic pain, anxiety and insomnia.
However nearly all of those claims are untested, said Dr Richard Miller, a professor of pharmacology at Northwestern University Feinberg School of Medicine in Chicago.
Cannabidiol or CBD has been shown to improve certain rare seizure disorders, he noted. In 2018, the U.S. Food and Drug Administration approved Epidiolex, a purified, pharmaceutical-grade CBD for those conditions.
Dr Miller added, “But all of the other 10,000 things CBD is supposed to do? We have no idea. I think the vast majority of it is fake.”
However cannabis clearly does have some medicinal use, according to Miller.
He added, “With respect to humanity’s experience with cannabis, people have taken it medicinally for thousands of ye ars. It was only in the last century that marijuana prohibition took hold making those years the anomaly.”
The research findings are based on responses from 808 cannabis users and 468 “controls.” All had chronic health conditions most often neurological disorders such as multiple sclerosis or epilepsy; chronic pain; or psychiatric conditions such as depression or anxiety.
Also all were seeking information from a nonprofit on medical marijuana use; people in the control group were not using cannabis but were considering it.
Overall, the study found, cannabis users scored a little lower on standard scales rating pain severity and anxiety and depression. They also reported better sleep quality.
Significantly, Dr Vandrey said, was the fact that cannabis users needed less health care: They were 46% less likely to have been hospitalized in the prior month, and 39% less likely to have visited an ER. And in their day-to-day lives, they tended to use fewer prescription medications, an average of 14% fewer.
Messrs Jane Allen, an analyst with the research institute RTI International in North Carolina, called the study’s recruitment strategy a limitation. Since participants consulted the nonprofit, they likely had “positive perceptions” about cannabis from the start”.
She said, “The study would be stronger and less susceptible to bias if recruitment had been through a cannabis-neutral channel.”
However to Dr Vandrey, the findings highlight the need for researchers to dig deeper into medicinal cannabis. Studies need to look, for example, at individual health conditions and the effects of a given CBD or THC product.
Dr Vandrey added, “If we’re going to legalize cannabis to be used as medicine, then we need to better understand how to use it as medicine.”
Dr Miller agreed. He said the new findings “add to the flow of data” that medicinal cannabis has benefits but the specifics remain unclear.
The research also found that only 27% of cannabis users said they were doing so under a doctor’s recommendation.
Dr Vandrey warned, “That’s concerning. So who is recommending it to them? And are their doctors aware they’re using it?”
He warned, there’s increasing evidence that cannabinoids can interact with certain medications.
Dr Vandrey suggested that if individuals are interested in using cannabis for medical reasons, they should consult their physicians. And do the research: “See if there’s evidence of safety and efficacy for your health condition,” he stressed.
For more on medical cannabis , keep on logging to Thailand Medical News.
7 Surprising Ways People Are Using CBD Oil—and What Doctors Really Think About It
This compound derived from marijuana won’t get you high, and it may have real health benefits, too.
Everywhere you click these days, it seems like someone on the internet is talking about cannabidiol—also known as CBD, a chemical compound derived from the cannabis plant. Online retailers market the extract (also known as hemp oil) as a remedy for a variety of ailments, celebrities swear by its healing powers, and the ingredient is popping up in nutritional supplements and beauty products, as well. There’s even a new FDA-approved drug derived from CBD.
Although cannabis can be used to make marijuana, CBD itself is non-psychoactive—meaning that it doesn’t get you high the way smoking or eating cannabis-related products containing THC (the plant’s psychoactive compound) can. Still, there’s a lot doctors don’t know about CBD and its effects on the body, and a lot consumers should understand before trying it.
To get a better idea, Health looked at the latest science and ran some of the most common CBD-related health and wellness claims by experts in the field. Here’s what researchers think about the way these products are being marketed, and what potential users should keep in mind.
To quit smoking
There’s been some buzz about CBD oil being helpful to people trying to quit cigarettes, and one small, short-term study published in 2013 in the journal Addictive Behaviors supports this idea.
A group of 24 smokers received inhalers with either CBD or a placebo substance and were encouraged to use those inhalers for a week whenever they felt the urge to smoke. Those with the placebo inhaler did not reduce their cigarette consumption at all during that week, but those with the CBD inhaler reduced theirs by about 40%.
The results “suggest CBD to be a potential treatment for nicotine addiction,” the study authors wrote—but they also admit that their findings are preliminary. Ryan Vandrey, PhD, a cannabis researcher and associate professor of psychiatry at Johns Hopkins University (who was not involved in the 2013 study), agrees that larger, longer-term studies are needed to know if CBD might be helpful for smokers looking to kick the habit.
For pain relief
Daniel Clauw, MD, professor of anesthesiology at the University of Michigan, believes that CBD may have real benefits for people living with chronic pain. He cites a recent clinical trial from pharmaceutical company Zynerba (for which Dr. Clauw has consulted) that found that a CBD-derived topical drug provided pain relief to patients suffering from knee osteoarthritis.
Zynerba is no longer pursuing a version of that drug for osteoarthritis, says Dr. Clauw, and there are currently no standard recommendations for what dosage or formulation of CBD (in either oral or topical form) might work best for pain relief. But he does want pain patients to know that CBD products may be worth a try—and that they may provide relief, even without the high that products with THC produce.
“I don’t think we have that many good drugs for pain, and we know that CBD has fewer side effects than opioids or even nonsteroidal anti-inflammatory drugs, which can cause bleeding and cardiovascular problems,” he says. “If I have an elderly patient with arthritis and a little bit of CBD can make their knees feel better, I’d prefer they take that than some other drugs.”
In skincare products
CBD appears to have anti-inflammatory properties, says Dr. Clauw, which is one reason the beauty industry has championed it as a new anti-aging ingredient in many skincare products and spa treatments.
Francesca Fusco, MD, a dermatologist based in New York City, recently told Health that CBD oil is a rich source of fatty acids and other skin-healthy nutrients, and that it may improve hydration and minimize moisture loss. A few studies have also suggested that CBD oil may inhibit the growth of acne, although this hypothesis has only been tested in laboratory cell cultures—not in actual humans.
As a treatment for autism
Parents of autistic children may look to CBD as a potential treatment, but they should know that research in this area is really just beginning, says Vandrey.
CBD has been shown to interact with the body’s endocannabinoid system, a network in the brain that seems to play a role in social behavior, circadian rhythm, and reward processing—all of which can be atypical in people with autism. For that reason, researchers are excited about a study that’s currently underway at the University of California San Diego about CBD’s potential as an autism therapy.
But besides the fact that no human trials have been conducted on CBD for autism, there’s another reason for potential patients (and parents) to weigh their options carefully. The industry is still unregulated—meaning that, in many states, there are no laws or inspections to ensure that a product’s ingredients match what’s listed on the label.
Research conducted by Vandrey and his colleagues has even shown that some CBD products contain significant levels of THC—which could get a child high and cause other unpleasant side effects. “This is an area that exists in a grey area of legality,” Vandrey says. “And because of that, anyone thinking about using cannabidiol, of any type, should proceed with caution.”
To treat seizure disorders
“In terms of solid evidence, the one thing we really know about CBD is that it can be helpful for rare childhood seizure disorders,” says Vandrey. (Beyond that, he adds, “there’s not yet sufficient evidence to support its use for any other reason.”)
Clinical trials have shown that the drug Epidiolex—a derivative of CBD—can help reduce seizures in children with two rare forms of epilepsy: Lennox-Gastaut syndrome and Dravet syndrome. In June, the FDA approved Epidiolex as the first prescription drug made from marijuana, for the treatment of these two conditions.
To fight cancer
When Olivia Newton-John was diagnosed with metastatic breast cancer in 2017, the actress’s daughter Chloe Rose Lattanzi posted on Instagram that her mother was using CBD oil as a treatment. Lattanzi also wrote online that cannabis “has scientifically proven properties to inhibit cancer cell growth.”
Lattanzi may be referring to studies that have been done in animals and in laboratory cell cultures, which have shown that cannabis may have anti-cancer effects. But there haven’t yet been any studies in humans that back this up, says Vandrey.
“I would argue that those types of effects have not always been very well translated and validated in human clinical trials,” says Vandrey. “The jump from one species to another can often be misleading, especially when we’re talking about a potential treatment for something as serious as cancer.”
In other words, the mainstream medical community doesn’t recommend marijuana or CBD products as a remedy for cancer. While these substances may relieve some side effects of cancer or of chemotherapy (like pain, nausea, and vomiting), they should not be used as a replacement for conventional, research-proven treatments.
To get our top stories delivered to your inbox, sign up for the Healthy Living newsletter
As a stress and anxiety buster
Actress Busy Philipps recently told Health that she’s a “strong proponent” of CBD and THC gummies, which she takes to help fight anxiety and panic attacks. Today’s consumers can also buy “calming” foods and beverages like hemp-oil tea and CBD-infused almonds; there’s even a brand of CBD biscuits for nervous dogs.
Informally, people have been using cannabis to relieve anxiety for years, says Dr. Clauw, although it was generally assumed that it was the THC—and the “high” that it produces—that was responsible for its stress-relieving effects. Recent research, however, suggests that CBD alone may have some anxiety-fighting power.
“It seems to have sort of a calming effect on the brain, although the precise mechanism by which it exerts these effects is not really well understood,” says Dr. Clauw. “I do recommend that patients try CBD first without THC, because you may be able to get the benefit without the side effects.”
What is CBD and what are its health benefits?
Far-reaching but mostly unsubstantiated claims about cannabidiol have made it a popular therapy for a variety of ailments. Hopkins expert Ryan Vandrey discusses the ‘cure-all’ myths associated with the drug and recent study findings.
By Marc Shapiro
/ Published Jan 3, 2020
Increasingly, products containing cannabidiol, or CBD, a chemical component of cannabis, are popping up at grocery stores, gas stations, drugstores, and internet marketplaces. Celebrated for its purported therapeutic effects and legal when derived from hemp—a form of the cannabis plant—CBD can be found in shampoos, hand lotions, skin creams, and even dog treats. Far-reaching medical claims tout its success at treating various conditions such as anxiety, acne, insomnia, addiction, inflammation, and Parkinson’s disease.
But such assertions often go far beyond what science has shown, according to cannabis researcher Ryan Vandrey, an associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. He and other researchers are working to understand the effects of the compound and what conditions it might actually help. He recently spoke with Dome about his research and his concerns about the growing CBD market.
Does CBD get you high? What does the research say?
THC, another chemical component of cannabis, drives most of the effects we typically associate with the drug, such as the subjective “high.” There’s this perception that CBD is not psychoactive, but I think that’s inaccurate. Research from our lab and others shows that CBD can produce subjective drug effects. CBD drug effects are different from THC and do not seem to produce intoxicating effects where performance or cognition is impaired. While that’s not a bad thing, impacting mood and behavior is a psychoactive drug effect. For example, caffeine is a psychoactive drug because it affects brain function and mood.
Are products that contain CBD safe?
There’s an inadequate regulatory framework to ensure that these products are tested, appropriately labeled, and free of contamination. There’s no way to tell how much a person should take or how to determine if it’s even helping their condition, and we still don’t know what kinds of patients are going to best benefit from CBD versus another medical intervention. Researchers are most commonly studying CBD’s application in anxiety, insomnia, post-traumatic stress disorder, pain and inflammation, and autism.
A sea change in CBD drug policy?
Hopkins experts discuss the DEA’s recent decision to schedule a marijuana-derived epilepsy medication as a Schedule V drug, making it the first federally sanctioned compound derived from the cannabis plant
Some people are taking CBD for general wellness, and we have no evidence that’s a good idea. Anytime you take a medication chronically, it’s going to impact your physiology. It could be harmful. It could interact with other medications in a substantial way.
The U.S. Food and Drug Administration was recently given regulatory power over hemp, and has since enacted certain restrictions on CBD. It is now illegal to market CBD by adding it to food or labeling it as a dietary supplement.
A JAMA study in which you participated shows that nearly a quarter of the CBD/hemp products sold on the internet contain THC even though THC wasn’t listed on the labels. What does that mean for the public?
Most people who use CBD are completely unaware of the possibility of THC exposure. With the legalization of hemp—which is simply cannabis with less than 0.3% THC—and hemp-derived products containing CBD, there’s potential for those products to have a significant impact on drug testing programs. My lab just completed our first CBD study, which showed that a single instance of vaping cannabis that has 0.39% THC in it (similar to the legal allowance in hemp of 0.3%) can result in a positive drug test for THC. We’re interested in determining whether using CBD may affect the outcomes of workplace drug tests and roadside tests for driving while intoxicated or under the influence.
“All told, I think there is a real therapeutic potential for cannabinoids, but we cannot abandon the methods used to bring all other medications to market.”
Also, depending on the amount used and route of administration, these products have the potential to produce impairing drug effects. So we need to ensure there are evaluation mechanisms that can differentiate between someone who is using a legal drug versus an illegal drug. Similarly, we need to be able to recognize the difference between a drug that can impair your ability to operate a vehicle versus one that does not.
What CBD studies is your team working on?
We’re characterizing the drug’s effects in healthy adults who are given a dose of CBD and looking to see whether there’s a difference if the drug is inhaled or swallowed. We’re also conducting long-term observational research on people who are using cannabis, hemp, and CBD products for medicinal purposes. We want to know why people are using it and look at their health outcomes.
We’re also looking at whether CBD’s effect changes when used in conjunction with THC.
Can you tell us a little about the initial findings from the long-term observational study?
We found that, among individuals with a variety of health problems such as epilepsy, chronic pain, autism, anxiety, and other serious health conditions, those who were using a cannabis product—people predominantly used CBD products—reported a better quality of life and satisfaction with health, pain, sleep, and mood compared with those who were not using cannabis products. When those who were not using cannabis at the time of our first survey later started using cannabis, they showed improvements in those same health measures that mirrored the differences between the cannabis users and nonusers in the beginning.
Though we can’t say definitively that CBD is effective for any of these health problems, the outcomes of this study highlight the need for additional research on hemp/CBD products in controlled clinical trials, especially for autism, anxiety, depression, multiple sclerosis, chronic pain, and epilepsy conditions other than Dravet syndrome and Lennox-Gastaut syndrome.
What’s your advice for someone who wants to try CBD?
My advice always is, first and foremost, to talk to your physician before you try any new drug, including CBD. Just because you can buy it at CVS and Walgreens, and because there’s generally no impairment and potential for abuse, doesn’t mean that it’s without risk and an appropriate treatment for you. That discussion should focus on what treatment options are available and what the relative potential for risk and benefit would be for each option.
I have the same recommendation about CBD products for pets. We have even less research to back up CBD as a treatment for them.
All told, I think there is a real therapeutic potential for cannabinoids, but we cannot abandon the methods used to bring all other medications to market. Data that can be used to determine efficacy, safety, dosing, and formulation is needed for each therapeutic area in which CBD is believed to be beneficial. We also must be mindful of gimmick products for which there is no reason to believe CBD is a meaningful addition.