CBD Oil For Inflammation

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<span><b>Introduction:</b> Some cannabinoids have been identified as anti-inflammatory agents; however, their potential therapeutic or prophylactic applications remain controversial. The aim of this systematic review was to provide a timely and comprehensive insight into cannabinoid-mediated pro- and anti</span> … CBD oil is one of the fastest-growing prescriptions among adults. Find out why it’s quickly becoming the go-to treatment for those suffering from chronic infl

The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies

Introduction: Some cannabinoids have been identified as anti-inflammatory agents; however, their potential therapeutic or prophylactic applications remain controversial. The aim of this systematic review was to provide a timely and comprehensive insight into cannabinoid-mediated pro- and anti-inflammatory cytokine responses in preclinical in vivo studies. Methods and Materials: A systematic search was conducted using PubMed, Web of Science, EMBASE, and Scopus. Eligible studies where cannabinoids had been evaluated for their effect on inflammation in animal models were included in the analysis. Data were extracted from 26 of 4247 eligible full text articles, and risk of bias was assessed using the SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) tool. Studies examined cannabidiol (CBD; n=20); cannabigerol (CBG; n=1); delta 9-tetrahydrocannabinol (THC; n=2); THC and CBD separately (n=1); and THC and CBD in combination (n=2). Results: Tumor necrosis factor alpha, interleukin (IL)-1β, IL-6, and interferon gamma were the most commonly studied pro-inflammatory cytokines and their levels were consistently reduced after treatment with CBD, CBG, or CBD+THC, but not with THC alone. The association between cannabinoid-induced anti-inflammatory response and disease severity was examined. In 22 studies where CBD, CBG, or CBD in combination with THC were administered, a reduction in the levels of at least one inflammatory cytokine was observed, and in 24 studies, some improvements in disease or disability were apparent. THC alone did not reduce pro-inflammatory cytokine levels (n=3), but resulted in improvements in neuropathic pain in one study. Conclusions: This review shows that CBD, CBG, and CBD+THC combination exert a predominantly anti-inflammatory effect in vivo, whereas THC alone does not reduce pro-inflammatory or increase anti-inflammatory cytokines. It is anticipated that this information could be used to inform human clinical trials of cannabinoids, focusing on CBD and CBG to reduce inflammation across a range of pathophysiological processes.

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Keywords: CBD; THC; anti-inflammatory; cannabinoids; cannabis; cytokines; inflammation; systematic review.

Conflict of interest statement

G.Z.S. and L.S.D. are part of the NICM Health Research Institute at Western Sydney University. As a medical research institute, NICM receives research grants and donations from foundations, universities, government agencies, individuals and industry. Sponsors and donors provide untied funding for work to advance the vision and mission of the Institute. The project that is the subject of this article was not undertaken as part of a contractual relationship with any organization other than the funding declared hereunder. It should also be noted that NICM conducts clinical trials relevant to this topic area, for which further details can be provided on request. G.Z.S. has received funding from Australian Natural Therapeutics Group to conduct investigator-initiated cannabis research; this company did not have any role in the conduct of this research.

CBD Oil and Inflammation: Why Some Patients are Saying Goodbye to Ibuprofen

Inflammation or swelling is the body’s natural way of repairing itself. But this healing process can sometimes cause pain or soreness. Inflammation can also be caused by arthritis and other conditions.

Inflammation causes more than physical discomfort, it can also lead to depression or a lack or motivation to get up and move about.

You may be like countless other people who immediately reach for the ibuprofen when it comes to treating pain associated with inflammation. But there’s an increasingly popular alternative way to deal with these symptoms. CBD (cannabidiol) oil is quickly becoming the go-to solution for those suffering from chronic pain due to inflammation.

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Dr. Khaleghi of the Pacific Rheumatology Medical Center believes in the healing effects of CBD and is at the forefront of this new medical frontier. If you’ve heard about CBD oil but are still wondering exactly what it is, here’s what you need to know.

What is CBD?

CBD is a cannabinoid — a compound that comes from the cannabis plant. However, unlike THC (tetrahydrocannabinol), which is another compound found in the cannabis plant, CBD does NOT contain any hallucinogenic effects or the “high” that some claim to get from THC.

Instead, CBD offers soothing, pain-reducing effects without the negative side effects associated with THC. This is why CBD is making an undeniable impact on the medical community. Just within the past couple years, the medical community has been forced to take a very serious look at cannabis, something that may have seemed ridiculous just a few years ago.

How does it work?

CBD oil is applied topically to the skin like a lotion. One jar of CBD oil lasts for a long time, as a little bit goes a long way. And because it isn’t a narcotic like other painkillers, and it’s not ingested like ibuprofen, CBD oil cannot be abused and is not addictive. And no, you won’t smell like marijuana after rubbing it into your skin. CBD oil is simply a more natural and healthy way to attack pain from the outside rather than the inside.

Because this treatment is relatively new, you may be skeptical about its healing abilities, However, in light of the rise in prescription painkiller abuse, it may be time to look to alternative solutions when dealing with or prescribing treatment for inflammation or swelling.

If you have questions about CBD oil or CBD in general, give us a call to schedule a consultation. We’d be happy to help you understand the science behind CBD.

Dr. Khaleghi is a board certified rheumatologist and takes pride in seeing his patients who suffer from inflammation leave with hope, mobility — and no more pain. Schedule a visit to Pacific Rheumatology Medical Center today by giving us a call or using the online scheduling tool.

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