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Cbd oil for people on dialysis

CBD Oil for Kidney Disease: Benefits, Side Effects, and Dosage

CBD may provide support for kidney disease through its anti-inflammatory, antioxidant, and analgesic benefits.

But there are some limitations to be aware of.

Here’s how you can get started using CBD oil today.

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According to research conducted by the American Kidney Fund, roughly 10% of the American public are believed to suffer from chronic kidney disease.

In this article, we’ll explore how to use CBD as a supplement for chronic kidney disease, how it works, and when you should avoid it.

Let’s get straight into it.

MEDICALLY REVIEWED BY

Updated on January 12, 2022

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Summary: Using CBD for Kidney Disease

Cannabis could be a useful aid in managing certain symptoms of kidney disease — which often includes chronic pain, nausea, emesis, anemia, itching, insomnia, and an overall lack of well-being

There’s evidence that CBD and other related cannabinoids can support the health of the kidneys during both acute and chronic kidney disease in mice — though this has yet to be confirmed with research on humans.

One of the main advantages of using CBD over other pain medications is that it doesn’t cause any additional damage to the kidneys.

Other pain medications — such as acetaminophen or opiate medications — are metabolized by the liver and eliminated through the kidneys. These drugs have been shown to cause damage to the sensitive cells making up the kidneys, which can lead to a worsening of the condition.

CBD is also metabolized by the liver but has been proven not to cause additional damage to the kidneys — making it a non-toxic option for managing kidney-related pain.

The Benefits of CBD for Kidney Disease:
  1. Potentially reduces pain associated with common side-effects of kidney disease
  2. May slow the progression of kidney disease
  3. Studies suggest it may lower inflammation of the kidneys
  4. Could help protect the kidneys from oxidative damage

What’s the Dose of CBD Oil?

Kidney disease is a severe disease so any potential treatment options should be discussed with a medical doctor. This condition can quickly lead to serious consequences.

With that said, many people with kidney disease are turning to CBD as an adjunctive treatment option along with other medications and diet/lifestyle modifications.

Finding the right dose of CBD can be a challenge, as the compound affects everybody differently.

Unfortunately, there isn’t much research highlighting the effective dose of CBD for kidney disease — most of the research done up to this point has been investigating the safety of using CBD with kidney disease (which is positive) and animal testing to explore how it works.

We can use dosage information from similar conditions, such as liver or cardiovascular disease which involve similar mechanisms of action. Usually, these conditions require higher doses of CBD to produce effects.

Therefore, it’s likely that the dose of CBD should be on the higher end of the spectrum to be useful for kidney disease.

Whenever using CBD (or any supplement for that matter) for the first time, it’s essential that you start with a small dose, and build up gradually over time once you know how it affects you individually.

We recommend starting at the low-strength dose and build up slowly over time to the medium or high-strength doses.

Calculating CBD Dosage Strengths By Weight

Unit of Measure Low Strength Medium Strength High Strength
Imperial (pounds) 1 mg every 10 lbs 3 mg every 10 lbs 6 mg every 10 lbs
Metric (kilograms) 1 mg every 4.5 kg 3 mg every 4.5 kg 6 mg every 4.5 kg

Using this information, you can calculate what a low dose, medium dose, or high dose of CBD may look like.

To simplify this for you, we’ve included a dosing chart based on weight and desired strengths.

Impact of Cannabis Oil on Nutrition in Hemodialysis Patients Study (ICON-HP Study) (ICON-HP)

The study will be performed in two parts: 1) The pharmacokinetic (PK) part and 2) The appetite and nutritional evaluation part.

The PK part of study will be conducted in open label manner on 10 end stage kidney disease (ESKD) patients receiving maintenance hemodialysis (MHD) treatment. For the PK part, a starting dose of cannabis oil -1 drop of 3% cannabis oil once a day [each drop contain 1.2 mg CBD (cannabidiol) and 1.2 mg of ∆9-THC (∆9-tetrahydrocannabinol)], was judged to be safe for a first-in-MHD patient’s administration. Escalation to the next higher dose and any dose adjustments of the next dose levels will be based on safety and tolerability results of the previously administered dose and available PK data of previous dose groups. Once the first dosage proved to be safe, there will be a 2 fold increase from the first dose level (2 drops once a day) to the second dose level. The dose levels will be increased by 2-fold from the previous dose level, until basal hunger and prospective consumption ratings assessed by the visual analogue scale (VAS) will increase at least by 10 mm between screening and the study visits (change-from-baseline) . PK parameters will be evaluated after first dosage administration and after dosage increased.

The appetite and nutritional evaluation part of study will be conducted as a 3-month, double-blind, parallel-group, placebo-controlled, single center study. The study population will include 30 ESKD patients receiving MHD treatment with different degrees of protein-energy wasting (PEW) defined as malnutrition-inflammation score (MIS) above 6. A total of 30 subjects will be randomized to treatment with either cannabis oil or matching placebo.

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