It started when I was about 14. The sides of my nose got really red. Then they got flaky. Then they got weepy. Then I got weepy. I didn’t love it. But I also had no recourse to address it, let alone fix it. I didn’t want to draw attention to it, so I just ignored my own face in the hopes that it would fix itself. Once The Science-based Facts About CBD Effects on the Skin: Data From the Library of Medicine CBD products have exploded onto the marketplace as a result of the farm bill that legalized hemp agriculture. Both oral and topical products are now being widely sold in states that allow CBD sales. Accompanying the hundreds of pro CBD Oil For Seborrheic Dermatitis Please note that Internet Explorer version 8.x is not supported as of January 1, 2016. Please refer to this support page for more information. JID Innovations
This CBD Oil Saved My Skin From Full Blown Painful Itchiness
It started when I was about 14. The sides of my nose got really red. Then they got flaky. Then they got weepy. Then I got weepy. I didn’t love it. But I also had no recourse to address it, let alone fix it. I didn’t want to draw attention to it, so I just ignored my own face in the hopes that it would fix itself. Once that was no longer an option, I went to the doctor.
I had seborrheic dermatitis, which is kind of like dandruff but red and scaly and on your face. Love that for me! I was quickly given a lotion whose only ingredients were sulfur and mineral oils, and sent on my way. In the years that followed, I treated seasonal and stress-related flare ups with soap-free face wash, cortisone cream, and that’s pretty much it. The idea of using a daily moisturizer—let alone an all-out face oil—was terrifying to my uneducated brain. My motto was pretty much “Don’t touch it!!”
In the last few years, however, I’ve become acquainted with a little concept called clean beauty and rose hydrosol and 100 percent argan oil have become my new best friends. I’ve been able to slowly decrease applications of the aforementioned medical lotion, as my new skincare regimen keeps my overactive sebum production in check. For the most part. Flare ups still happen. That’s where CBD comes in.
As you can imagine, working at Miss Grass has meant CBD has infused itself into almost all aspects of my life. But only now, having been enabled by our ecommerce manager, have I tried incorporating a high-strength CBD oil into my daily skincare regimen. And not just any CBD oil.
I’m talking about the luxe leaders of CBD and skin, Lord Jones. I’m talking about their most potent product yet; their Royal Oil. I set myself the task of using it every day—as a facial oil and as a tincture—and this (not to be dramatic) is my story.
Like everything related to cannabis, some initial research into the efficacy of CBD as a treatment for skin buggers like dermatitis as yielded promising results, but there’s not enough studies at this point to know why, when, and how it all works. Generally speaking, managing skin issues via the endocannabinoid system (ECS) makes sense.
After all, the skin that covers our bods has a functioning ECS going on, right there. Which makes sense, given the skin’s role in maintaining homeostasis and acting as the vanguard of the human body in fighting off injury and infection.
The superstar endocannabinoid receptors, CB1 and CB2, are present in practically all cell types of the skin, too. These guys help prevent inflammation, and with some help from CBD, they have the potential to do a lot more. One study from Nottingham University points to the potential for CBD to play a role in the slowing down of the proliferation of skin cells linked to skin like mine. Another 2014 study published in the journal of the American Society for Clinical Investigation proposed that CBD also slows down the secretion of sebum a.k.a. literally the cause of seborrheic dermatitis.
Having researched the above, and with all signs pointing to promising, I set about covering my face in CBD oil at any opportunity. And at 1000mg of CBD per 30ml bottle of Royal Oil, that was a lot of CBD.
My (New) Royal Regimen
The potency of Royal Oil is what it’s known for, as you can imagine. Each full dropper contains about 40ml of CBD. Normally, that’d be enough to get a lightweight with no prior CBD experience a little fuzzy-headed. But Lord Jones products contain broad spectrum CBD; they contain all the natural cannabinoids and terpenes, minus the trace amounts of psychoactive THC. So even if you drank the whole bottle (please don’t) you wouldn’t be a trace high.
But back to my skin. It responds much better to all-natural ingredients, it turns out. And for skin care purists, you’ll be pleased to know that Royal Oil contains two essential ingredients; broad spectrum CBD suspended in grape seed oil. No flavorings, colors, or additives—just a subtle, gorgeous cannabis scent.
Having stalked the Sephora reviews for Royal Oil to compare my experience, it seems that some people have found applying ample amounts of grape seed oil to their face causes them to break out. Not to brag, but I’m not one of those people. It’s been almost two weeks and I have the same amount of pimples I always do. Which is average. If anything, that amount’s dropped slightly—no small feat considering my experimentation overlapped with the onset of my period.
How’s the dermatitis, you ask? Zero flare ups. At one point about a week ago, I found I was developing some related dryness on my neck. I slapped it with Royal Oil each night before bed (the only time face oils should be applied, by the way) and after three or four nights? It calmed all the way down to non-existent status. And considering that means it went all the way from red and scaly, to straight up my-skin-color and smooth, that’s kind of a big deal.
But my favorite part of using Royal Oil is the ritual of a multipurpose CBD oil with such potency. In the mornings, I would drop some into my AM beverage (a protein drink, most days) and at night, I would put a dropper’s worth under my tongue and another on my face after cleansing and hydrosol spritzing. Then I would jade roll that shit right into my epidermis with all the tenderness and self-love I could muster.
Yes, I’m describing all of this in past tense, but believe me: I’ll be doing this exact same thing with this exact product for the rest of my life. At least while I have a Miss Grass staff discount code. Because at $100 a pop, it’s an investment for sure. But hey, this is your largest organ we’re talking about.
What is Actually Known About CBD’s Effects on Skin
CBD products have exploded onto the marketplace as a result of the farm bill that legalized hemp agriculture. Both oral and topical products are now being widely sold in states that allow CBD sales. Accompanying the hundreds of products now on the market are a multitude of therapeutic “claims” that these products can treat a wide variety of medical problems, including pain, arthritis, psoriasis, aging and even cancer. Given all of the claims for benefits of using CBD products, it is important to understand what the real science and clinical evidence is regarding CBD’s effects both orally and topically.
First of all, evidence that cannabinoids occur naturally in the body dates back over 60 years. Since that time, the Endocannabinoid System (ECS) has been studied in depth. The ECS is made up of:
- the endocannabinoids (like CBD) that interact with the receptors of the ECS
- the main receptors for cannabinoids, CB1 and CB2, which are found in the central and peripheral nervous system as well as on skin cells
- various specific enzymes that either synthesize cannabinoids or degrade them. The body actually makes its own cannabinoids and these are called endocannabinoids
However, the cannabinoids that have received all the attention lately are the phytocannabinoids that are derived from plants, like cannabis and hemp.
The Take Home Lesson
For those that don’t wish to read the full report below regarding what is really known about CBD effects on the skin when applied topically, the take-home message is:
- As of April, 2021, there are NO peer-reviewed publications of controlled clinical studies that describe any benefit of CBD to the skin when applied topically. There are three non-controlled “anecdotal” human studies, several mice and rat studies, and many studies of CBD effects on cultured skin cells. So, at present, we simply don’t know if topically applied CBD products provide ANY benefits.
Although there has been a lot of research regarding cannabinoids, the only in depth clinical studies that have been conducted have looked at effects of cannabinoids after either ingesting, inhaling or injecting the cannabinoids. There have been essentially no published controlled clinical studies on the effects of topically applied cannabinoids. This is surprising in light of the numerous claims showing up on the internet about all the wonderful things cannabinoids can do. If one wants to know what “claims” that show up on the internet are true and which are false, the ONLY way to accurately assess truth from fiction is to do your research on the Library of Medicine’s database. Pubmed (https://www.ncbi.nlm.nih.gov/pubmed), the Library of Medicine’s online searchable database lists every peer-reviewed scientific publication related to a given subject.
A search of the Pubmed database using the search words cannabidiol (CBD) turned up over 3000 publications that have appeared over the years, with most dealing with the oral use of CBD to either treat epilepsy (the only FDA approved CBD medicine is Epidiolex) or to reduce pain. Many other published studies have focused on analyzing CBD content in various cannabis extracts. When the term “cannabidiol” was combined with “skin”, only 62 publications were found. Of these 62, there were only THREE clinical studies on the topical effect of cannabinoids on skin, and these were carried out with very small numbers of patients, which does not provide any statistically significant results. As a result these studies are considered “anecdotal” and not controlled studies. A quick summary of all the results of peer reviewed scientific articles on cannabinoids is listed below.
- Although there have been a few mice and rat studies on topically applied cannabinoids, there have been only three published reports of clinical studies on the topical use of cannabidiol.
- In one study patients with mild to moderate scalp psoriasis or seborrheic dermatitis were given a shampoo containing cannabidiol. After 14 days of use, the level of itching and redness had decreased in the patients.
- In a second very small study of 16 patients, they were asked to evaluate the effect of a topical cannabidiol lotion on their eczema. After 2 weeks of use, the patients “self-reported” an modest improvement in the severity of their eczema.
- In a third small study, patients treated topically with 8% CBD reported having less nerve pain.
- NOTE: in addition to the above studies, a non-clinical study with only 3 individuals suffering from a rare skin blistering disease, epidermolysis bullosa, applied a topical CBD oil to their skin and all 3 reported less blistering.
- A topical preparation of CBD was shown to reduce inflammation and swelling in the foot of a mouse injected with an irritant.
- Rats treated topically with CBD and then exposed to a UVB lamp showed protection of keratinocytes from apoptosis (cell death caused by UV radiation). Whether or not CBD was simply acting as a sunscreen was not determined.
- Mice treated on the ears with a tumor promoter to trigger inflammation showed less ear edema (swelling) in the ear treated with CBD.
- Changes in the proteome profile of UVB treated fibroblasts.
- CBD induces the expression of antioxidant enzyme genes in keratinocytes treated with UVR.
- CBD blocks the NF-kB pathway that leads to the activation of inflammatory genes in UVR stimulated keratinocytes.
- CBD reduces keratinocyte proliferation, which may be useful for treating psoriasis but may not be good for normal skin turnover.
- CBD reduces free radical (ROS) levels in keratinocytes.
- CBD is a gene suppressor and can lower keratin levels in keratinocytes
- CBD stimulates melanogenesis (pigmentation) in human melanocytes.
- Hemp extract protects keratinocytes and fibroblasts from hydrogen peroxide toxicitiy by blocking ROS (free radicals) and by inhibiting the inflammatory mediator, PGE-2.
- CBD reduces sebum production in cultured sebocytes, which might be useful for acne.
- CBD increases activity of NRF-2 and this leads to increased antioxidant (superoxide dismutase). CBD also prevented cells damaged by UVB from undergoing apoptosis (cell death). Note: the value of keeping potentially mutated cells alive may not be a good thing.
- CBD may lower ROS levels.
- Flax extract inhibited inflammation but stimulated MMPs in a wound healing model, which may be good for wound healing but bad for maintenance of the dermal matrix.
As you can see, research on CBD is in its infancy and there is almost NO clinical data showing any beneficial effects of topical CBD on human skin. Given the available data, what effect on the skin might we expect to see if we applied CBD topically?
- CBD and keratinocyte growth: The keratinocytes in our skin are dividing all the time at the basal layer of the epidermis and from there they migrate to the skin’s surface to replace those dead, cornified keratinocytes that make up the stratum corneum. The stratum corneum is a critically important protective barrier that protects us against environmental damage by pathogenic bacteria, fungi, parasites, viruses, UV radiation and water loss. We know that in a young person, the epidermis “turns over” about every 40-45 days (recent studies suggest that the complete turnover of the epidermis takes longer than the 30 day time period that has been used for years). We also know that this “turnover rate” decreases as you get older, due, in large part, to a reduction in the proliferation rate of keratinocytes at the basal layer of the epidermis (age can cause up to a 50% reduction in keratinocyte mitosis). Thus, fewer keratinocytes migrate to the surface and the skin becomes thinner as we age. An article in the Journal of Dermatological Science (Wilkinson and Williamson (2007), J.Dermatol Sci: 45: 87-92) describes the inhibition of keratinocyte proliferation/growth by cannabinoids. In addition, a more recent research study has shown that cannabidiol, as well as other cannabinoids, inhibit the expression of genes that code for important keratinocyte proteins (Pucci, M. et al (2013); Br.J. Pharmacol. 170: 581-591). These proteins, including Keratin 1 and 10, and involucrin, are important structural components of the epidermis. Since these proteins are critical for the normal development, strength and barrier properties of the stratum corneum, inhibiting their production and lowering their levels in the skin, weakens the skin’s barrier.
So, although the use of CBD in slowing the proliferation of keratinocytes might be helpful in reducing psoriatic plaques caused by rapidly growing keratinocytes, and might even help treat skin cancer, there is no data at present that its use in normal skin care and “anti-aging” products will provide any benefits. And based on the available data, topical CBD might cause skin thinning and a loss of barrier function.
- CBD Effects on Inflammation: At the present time there is no scientifically published human data on any anti-inflammatory effect of topically applied A few studies with cell cultures have shown that CBD can lower the level of the inflammatory mediator, TNF-alpha, in leukocytes, block IL-6 and IL-8 production in human monocytes and macrophages, lower COX-2 (PGE-2) expression in macrophages, and block inflammatory cytokines in keratinocytes (Pellati, F; et al; (2018) Biomed Res. Intl. ID. 1691428). Finally, a recent publication has shown that Flax Fiber (which contains several chemicals, including CBD) might be useful as a wound dressing to accelerate healing. Recently, a derivative of CBD, VCE-004, was found to INHIBIT collagen production in human dermal fibroblasts (Del Rio, C., et al., 2018, Br.J.Pharmacol. 175:3813). For a very recent review on what is known about CBD effects on inflammation see Baswan, S.M et al. (2020) Clinical, Cosmetic and Investigational Dermatology. 13:927-942. So although cell culture studies suggest that CBD may provide anti-inflammatory benefits, at present, there are no clinical studies that demonstrate any anti-aging or anti-inflammatory effects of CBD when applied topically to the skin.
- CBD Stimulates Pigmentation A recent study on human melanocytes grown in culture found that CBD can stimulate melanogenesis in these cells by increasing tyrosinase activity and by activating a number of melanogenic specific genes ( Hwang, YS. Et al (2017) Chem. Biol. Interact. 273: 107-114). Given this finding, while topical CBD might be useful as a “tanning stimulator” it may aggravate an existing hyperpigmentation (age spot) condition.
- CBD Inhibits Sebum Production One of the potentially beneficial uses of a topical CBD product might be for controlling acne breakouts. A recent publication has shown that CBD can reduce sebum production in human sebocytes (Olah, A et al. (2016), Exp. Dermatol. 25:701-707. While retinoic acid also inhibits sebum production, and improves acne, further research might find that CBD provides the same benefit without the redness, and drying seen with the use of topical retinoic acid.
- CBD Reduces Neuropathy Pain. One recent study (Xu, DH. et al. 2019, Curr.Pharm.Biotechnol.) conducted with a small group of patients (29) showed that an 8% topical solution of CBD could reduce pain caused by neuropathy.
- CBD Inhibits Growth of Cancer Cells One of the more promising effects of CBD is its ability to slow the growth rate of cancer cells, including breast cancer. The mechanism of action of CBD likely involves an antagonism of one or both of the endocannabinoid receptors, CB1 and CB2. Both of these receptors play a role in tumor progression, with CB2 playing the greater role in stimulating breast cancer growth and tumor aggressiveness. By blocking the activity of these receptors, CBD lower cancer cell prolilferatoin and also causes cancer cell apoptosis (cell death). For an excellent review on CBD and breast cancer, see Kiskova, T. et al. (2019) Intl. J. Molec.Sci. 20: 1673-1694.
In summary, there is considerable peer-reviewed scientifically credible research that shows positive effects of oral CBD on anxiety, stress, and aggressiveness, and on preventing epileptic seizures. In fact, the only FDA approved CBD drug for epilepsy is Epidiolex, a drug that is effective in reducing the frequency of seizures. In addition, there is growing evidence that CBD may be useful in reducing the growth rates of some cancers.
At present there have been only 3 published, very small clinical studies on the effectiveness of topical CBD in treating any skin problem; one on the use of CBD for treating scalp psoriasis/seborrheic dermatitis, one that involved only patient “self- evaluation” on the benefit of topical CBD for eczema, and finally, one small study where patients used a topical CBD lotion to reduce nerve pain. Research on human cells grown in culture suggests that CBD does have some anti-inflammatory effects. Finally, there is currently no published data that topical CBD provides any benefits for normal skin, and no data showing any anti-aging benefits.
CBD Oil For Seborrheic Dermatitis
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In recent years, cannabinoid (CB) products have gained popularity among the public. The anti-inflammatory properties of CBs have piqued the interest of researchers and clinicians because they represent promising avenues for the treatment of autoimmune and inflammatory skin disorders that may be refractory to conventional therapy. The objective of this study was to review the existing literature regarding CBs for dermatologic conditions. A primary literature search was conducted in October 2020, using the PubMed and Embase databases, for all articles published from 1965 to October 2020. Review articles, studies using animal models, and nondermatologic and pharmacologic studies were excluded. From 248 nonduplicated studies, 26 articles were included. There were 13 articles on systemic CBs and 14 reports on topical CBs. Selective CB receptor type 2 agonists were found to be effective in treating diffuse cutaneous systemic sclerosis and dermatomyositis. Dronabinol showed efficacy for trichotillomania. Sublingual cannabidiol and Δ-9-tetrahydrocannabinol were successful in treating the pain associated with epidermolysis bullosa. Available evidence suggests that CBs may be effective for the treatment of various inflammatory skin disorders. Although promising, additional research is necessary to evaluate efficacy and to determine dosing, safety, and long-term treatment guidelines.
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Cite this article as: JID Innovations 2022;X:100095
These authors contributed equally to this work.
© 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.
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