Does CBD help with arthritis pain?
If you have chronic arthritis pain, you may be wondering about cannabidiol (CBD) as a treatment. CBD, along with delta-9-tetrahydrocannabinol (THC) and other chemicals, is found in marijuana. But unlike THC, CBD is not “psychoactive” — that is, it does not cause the intoxication or high associated with marijuana use.
There’s a good chance you’ve tried it already: according to a Gallup poll in August of 2019, about 14% of Americans report using CBD products, and the number one reason is pain. The Arthritis Foundation conducted its own poll and found that 29% reported current use of CBD (mostly in liquid or topical form), and nearly 80% of respondents were either using it, had used it in the past, or were considering it. Of those using it, most reported improvement in physical function, sleep, and well-being; of note, a minority reported improvement in pain or stiffness.
Perhaps you’ve been tempted to try it. After all, most types of arthritis are not cured by other treatments, and CBD is considered a less addictive option than opiates. Or maybe it’s the marketing that recommends CBD products for everything from arthritis to anxiety to seizures. The ads are pretty hard to miss. (Now here’s a coincidence: as I was writing this, my email preview pane displayed a message that seemed to jump off the screen: CBD Has Helped Millions!! Try It Free Today!)
What’s the evidence it works? And what do experts recommend? Until recently, there’s been little research and even less guidance for people (or their doctors) interested in CBD products that are now increasingly legal and widely promoted.
But now, there is.
A word about arthritis pain
It’s worth emphasizing that there are more than 100 types of arthritis, and while pain is a cardinal feature of all of them, these conditions do not all act alike. And what works for one may not work for another. Treatment is aimed at reducing pain and stiffness and maintaining function for all types of arthritis. But for certain conditions, such as rheumatoid arthritis, conventional prescription medications are highly recommended, because these drugs help prevent permanent joint damage and worsening disability.
In addition, individuals experience pain and respond to treatment in different ways. As a result, it’s highly unlikely that there is a single CBD-containing product that works for all people with all types of arthritis.
What’s the evidence that CBD is effective for chronic arthritis pain?
While there are laboratory studies suggesting CBD might be a promising approach, and animal studies showing anti-inflammatory and pain-relieving effects, well-designed studies demonstrating compelling evidence that CBD is safe and effective for chronic arthritis pain in humans do not exist. A randomized trial of topical CBD for osteoarthritis of the knee has been published, but in abstract form only (meaning it’s a preliminary report that summarizes the trial and has not been thoroughly vetted yet); the trial lasted only 12 weeks, and results were mixed at best. One of the largest reviews examined the health effects of cannabis and CBD, and concluded that there is “substantial evidence that cannabis is an effective treatment for chronic pain in adults.” But there was no specific conclusion regarding CBD, presumably because definitive studies were not available.
Of course, there is anecdotal evidence and testimonials galore, including reports of dramatic improvement by people who tried CBD in its various forms (including capsule, liquid, topical, and spray) for their pain. But we are still waiting for well-designed, scientifically valid, and rigorous clinical trials (such as this one in progress) that are so badly needed to answer the question of just how helpful CBD may be to people with chronic arthritis pain.
Are there downsides to CBD treatment?
As with any treatment, there can be downsides. CBD is generally considered safe; however, it can still cause lightheadedness, sleepiness, dry mouth, and rarely, liver problems. There may be uncertainty about the potency or purity of CBD products (since they are not regulated as prescription medications are), and CBD can interact with other medications. For pregnant women, concern has been raised about a possible link between inhaled cannabis and lower-birthweight babies; it’s not clear if this applies to CBD. Some pain specialists have concerns that CBD may upset the body’s natural system of pain regulation, leading to tolerance (so that higher doses are needed for the same effect), though the potential for addiction is generally considered to be low.
There is one definite downside: cost. Prices range widely but CBD products aren’t inexpensive, and depending on dose, frequency, and formulation, the cost can be considerable — I found one brand that was $120/month, and health insurance does not usually cover it.
Are there guidelines about the use of CBD for chronic arthritis pain?
Until recently, little guidance has been available for people with arthritis pain who were interested in CBD treatment. Depending on availability and interest, patients and their doctors had to decide on their own whether CBD was a reasonable option in each specific case. To a large degree that’s still true, but some guidelines have been published. Here’s one set of guidelines for people pursuing treatment with CBD that I find quite reasonable (based on recommendations from the Arthritis Foundation and a recent commentary published in the medical journal Arthritis Care & Research):
- If considering a CBD product, choose one that has been independently tested for purity, potency, and safety — for example, look for one that has received a “Good Manufacturing Practices” (GMP) certification.
- CBD should be one part of an overall pain management plan that includes nonmedication options (such as exercise) and psychological support.
- Choose an oral treatment (rather than inhaled products) and start with a low dose taken in the evening.
- Establish initial goals of treatment within a realistic period of time — for example, a reduction in knee pain that allows you to walk around the block within two weeks of starting treatment; later, if improved, the goals can be adjusted.
- Tell your doctor(s) about your planned and current CBD treatment; monitor your pain and adjust medications with your medical providers, rather than with nonmedical practitioners (such as those selling CBD products).
- Don’t make CBD your first choice for pain relief; it is more appropriate to consider it if other treatments have not been effective enough.
- Don’t have nonmedical practitioners (such as those selling CBD products) managing your chronic pain; pain management should be between you and your healthcare team, even if it includes CBD.
- For people with rheumatoid arthritis or related conditions, do not stop prescribed medications that may be protecting your joints from future damage; discuss any changes to your medication regimen with your doctor.
The bottom line
If you’re interested in CBD treatment for chronic arthritis pain or if you’re already taking it, review the pros, cons, and latest news with your healthcare providers, and together you can decide on a reasonable treatment plan. Depending on the type of arthritis you have, it may be quite important to continue your conventional, prescribed medications even if you pursue additional relief with CBD products.
We may not have all the evidence we’d like, but if CBD can safely improve your symptoms, it may be worth considering.
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About the Author
Robert H. Shmerling, MD , Senior Faculty Editor, Harvard Health Publishing
Dr. Robert H. Shmerling is the former clinical chief of the division of rheumatology at Beth Israel Deaconess Medical Center (BIDMC), and is a current member of the corresponding faculty in medicine at Harvard Medical School. … See Full Bio
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Best CBD Oils for Arthritis and Joint Pain Reviewed of 2022
As many as 54 million Americans are diagnosed with arthritis every year. According to NHIS data, it’s the leading cause of work disability leave in the United States.
Arthritis can be a real pain — literally and figuratively. The disorder often brings a lowered quality of life for those affected, forces people to take time off work, and makes it difficult to exercise and remain in good shape. Many people are therefore looking for an effective form of pain management to help with the disorder.
One of the most popular arthritis-supportive supplements being used today is cannabidiol (CBD) — one of the primary active ingredients in the cannabis plant.
Can CBD really help with arthritis? What’s the best CBD oil for arthritis?
We’ll explore these questions in detail in the article below. I’ll give you my top 5 CBD oils for arthritis pain, and give you some valuable insight into how to choose the best CBD oils for the job on your own.
This is a big topic so let’s dig in.
Best CBD Oils for Arthritis: Our Top 6 Brands of 2022
If you’re reading this article, you’re probably interested in finding a CBD product that can help you with your arthritis symptoms.
For those of you who want to understand how CBD works for arthritis, and what else you can do to make the effects of CBD even better, keep reading the sections below. If you’re simply looking for the best CBD oil to take, here’s a list of my top five CBD oils — including a breakdown of why I think it’s such a strong option.
Let’s dig into the list.
1. Royal CBD (Most Potent)
Get 15% off all Royal CBD products. Use code “CFAH” at checkout.
|Total CBD Content||250 – 2500 mg|
|Available Flavors||Natural, Peppermint, Vanilla, Berry|
|Potency||8.3 – 83.3 mg/mL|
What We Like About Royal CBD Oil:
A newcomer to the scene, Royal CBD is a premium manufacturer opting for high-grade organic ingredients in all its CBD products — including this full-spectrum hemp oil. The company’s product range is pretty simple, featuring only CBD oil, capsules, gummies, and some CBD-infused topicals.
The oil and capsules are full-spectrum extracts, while the gummies are made with a 99% pure CBD isolate. This oil has a few different options — you can choose between flavors like mint, berry, vanilla, or unflavored, and three separate potencies — 250 mg, 500 mg, 1000 mg, and 2500 mg of CBD per 30 milliliters (1 ounce) bottle. The strongest option carries 83.3mg of CBD in each milliliter.
For the best value, I recommend you aim for the higher potency option. This product has a higher initial cost than the others, but comes at a slight discount and will last a very long time — even if you use CBD on a daily basis. Only a few drops are needed to get a healthy dose of CBD.
If you don’t like the taste of natural CBD oil you can get their capsules instead. These come in an easy-to-swallow soft gel form and contain 25 mg per capsule.
All Royal CBD products are tested in third-party laboratories to ensure each batch is clean, has consistent levels of CBD, and is free from any potential contaminants.
- Made with organic Colorado-grown hemp
- All products are made with supercritical CO2 extraction
- You can buy both full-spectrum and CBD isolate products
- The highest potency bottle delivers 83.3 mg/mL
- Every batch of product has been tested by a third-party laboratories
- These products are priced on the higher end, although well justified
2. Gold Bee (Best Organic Formula)
- Made from US-grown, organic hemp
- Contains full-spectrum CBD
- 1200 mg of CBD per bottle (40 mg/mL)
- Extracted with supercritical CO2
- Delicious Kiwi flavor
- Sweetened with organic honey
- Third-party tested for cannabinoid content and purity
- Only one concentration available
- Limited flavor options
What We Like About Royal CBD Oil:
When it comes to arthritis, the quality of ingredients is paramount, as any pro-inflammatory compound can actually worsen your symptoms. With Gold Bee, this isn’t a problem, as the brand sells all-organic CBD oils formulated with full-spectrum hemp extracts. The hemp used by the company comes from organic farms in Colorado and is gently extracted with supercritical CO2 to provide the highest purity and consistent potency.
The full-spectrum of cannabinoids means you’re getting the synergistic effects from all naturally-occurring compounds in hemp, including the supportive cannabinoids and terpenes. As a result, you need less CBD to achieve the desired results than you would with CBD isolate. The Gold Bee CBD oil packs 1200 mg of CBD in a 30-mL bottle, translating into 40 mg of CBD daily. The dosage fits within the most common range for daily use.
Gold Bee also doesn’t use artificial flavorings and sweeteners in its products. The kiwi version of the CBD oil is infused with natural terpenes and sweetened with organic honey from Brazillian rainforests. The entire Gold Bee product line is rigorously tested in third-party laboratories for potency and purity.
|Total CBD Content||100 – 600 mg|
|Potency||1.6 – 10 mg/mL|
What We Like About CBDPure Hemp Oil:
CBDPure was founded in 2016 by cannabis aficionados from Colorado. The company has a simple mission — to make high-quality CBD oils made from organic hemp.
Although the company only sells CBD oil and capsules, it’s perfected both of these products. These extracts are made with supercritical CO2 and tested in third-party laboratories for quality assurance.
When it comes to CBDPure hemp oil, it isn’t as potent as those offered by Royal CBD — so if you’re looking for something high potency CBDPure may not be the best option available. However, if you want something cheap that maintains a high level of quality — CBDPure is an excellent choice.
CBDPure has an incredible return policy — which suggests the founders truly stand by their products. If you don’t like the product you can return it for 100% money back within 90 days. Most other CBD companies only offer this deal for 14 or 30 days, so this says a lot about the integrity of CBDPure as a company.
- CBDPure products are sourced from organic hemp grown in Colorado
- The company uses supercritical CO2 to make its extracts
- 100% Satisfaction Guaranteed program (full refund within 90 days)
- Narrow product range
- The oil is slightly less potent than Royal CBD
4. Hemp Bombs
|Total CBD Content||300 – 5000 mg|
|Available Flavors||Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon|
|Potency||10 – 1166.6 mg/mL|
What We Like About Hemp Bombs:
Hemp Bombs are one of the longest-standing companies in the CBD space. They’ve been around for years now, dating back before the CBD boom. As a result, the company has had a chance to become well-established in the industry, and have a loyal customer base as a result.
Although the branding makes these oils resemble a gas station brand of an energy drink — the oil contained inside is nothing to scoff at.
Hemp Bombs is able to use its large presence in the industry to source some of the best hemps in the country. They process all the hemp within the United States in GMP-certified labs. The company chose to use a CBD isolate for this oil rather than a full-spectrum extract. Using CBD isolate is cheaper and more accurate than full-spectrum products, but lacks the synergistic benefits of the entire cannabinoid and terpene profile — a concept referred to as the entourage effects.
The real benefit of using a CBD isolate is that this is the only way to guarantee the product contains no THC — which is the psychoactive cannabinoid responsible for producing the high from marijuana plants.
Hemp Bombs, like the others on this list, conducts extensive third-party testing on every batch of hemp extract that comes out of its facilities. This is the only way to ensure complete transparency and build trust with consumers. Hemp Bombs publishes these test results on the website for anybody to see — and includes the entire gamut of testing (heavy metals, cannabinoid profile, residual solvents, and microbial contaminant testing).
- Made from high-grade CBD distillate
- Comes in all different flavors and potencies
- Third-party tested for transparency
- Lacks the benefits of the entourage effect
- Flavored with synthetic flavoring agents
5. Nuleaf Naturals
|Total CBD Content||240 – 4850 mg|
What I Like About Nuleaf Naturals:
Nuleaf Naturals has the simplest product lineup I’ve ever seen. The company only offers one oil — a 48 mg/mL full-spectrum hemp extract. They use this same oil for every product offering.
When you go to the company website, you’ll find you can buy this oil in all different bottle sizes — but the oil itself is exactly the same. Even the pet oil options the company sells use this exact same extract.
The benefit of using just one oil is that Nuleaf Naturals can put all their attention and energy into this one product — doing everything they can to make it as top-notch as possible. And that’s exactly what they’ve done.
This oil is one of the best tastings and has some incredibly powerful effects compared to many of the other oils I’ve tried.
In order to even qualify for my top 5 list, the company has to offer third-party testing. I can’t trust the test results from a company doing their own testing. Nuleaf Naturals remains up to date with ordering third-party tests for every batch produced by the company. You’ll find a new test uploaded to the company website every two or three months as they release new batches of products. I have a look at these tests every time I order a bottle and have yet to find anything that stands out.
Every test I’ve seen from Nuleaf Naturals proves the oil is free from contaminants like heavy metals or pesticides, and the potency is almost always exactly the advertised potency. Occasionally a batch will come out that’s 2-5% off the advertised amount — which is expected for full-spectrum extracts.
- Simple product lineup
- Offers oils for both humans and pets
- CBD oil comes in all different bottle sizes to support any budget
- No flavor options available
- All products use the same hemp oil
|Total CBD Content||1000 – 2000 mg|
|Potency||33.3 – 66.6 mg/mL|
What I Like About Medterra:
This is a new product offered by the CBD giant Medterra. This company specializes in making broad-spectrum hemp extracts. This means the oil contains CBD, and most of the other supplemental cannabinoids like CBC, CBG, CBN, and THCV — but all traces of the psychoactive THC have been removed.
Medterra is intimately involved in the cultivation process for the hemp they use to make this oil — which allows the company to control the amount of pesticide used, and the timing of the harvest. These factors play a big role in the overall quality of the oil. Most other CBD companies buy hemp from farms located around the United States or Canada and have little control over the growing process.
Like any high-end CBD oil, this product has been thoroughly tested by both Medterras analysis lab, and independent laboratories.
Medterra sells a lot more than just CBD oils — you can also buy topicals, capsules, and pet treats.
- Medterra has complete control of the entire manufacturing process from seed to bottle
- Extensive third-party testing
- Broad-spectrum THC-free hemp oil
- Limited bottle sizes and flavor options
- This oil is heavily processed
What is Arthritis?
Arthritis is one of the most common causes of disability in the United States. Millions of people in the United States alone suffer from debilitating joint pain and inflammation from arthritis.
The disease causes severe inflammation and pain, as well as swelling and loss of function in the joints.
There are two main types of arthritis:
- Rheumatoid arthritis — This form of arthritis is an autoimmune disease. This means that the cause of inflammation is triggered by our own immune systems. White blood cells mistakenly attack and destroy our own joint tissue, causing a cascade of inflammatory processes in the joints — causing them to swell up and feel hot and sore. This form of arthritis can affect any joint but tends to focus on the larger joints such as the knee, hips, elbows, and knuckles.
- Osteoarthritis — This form of arthritis is caused by physical trauma and wear and tear rather than the immune system. This form of arthritis is common in athletes and older people. The condition begins with a low-grade inflammation in the joint itself, which causes the degeneration of protective cartilage and synovial fluid (lubrication for the joints). As the joint tissue becomes damaged, inflammation and pain worsen and reduce the mobility of the joint. This condition is degenerative — which means it tends to worsen over time.
All forms of arthritis have the same basic symptoms — pain, inflammation, and reduced mobility of one or more joints. Despite having radically different underlying causes, CBD has become extremely popular among arthritis sufferers in recent years.
CBD Oil & Arthritis: Can it Help?
Let’s explore how CBD works, and why it’s become so popular among arthritis patients.
CBD is one of the active ingredients in hemp plants (Cannabis sativa). This phytochemical is completely non-psychoactive, which means it won’t cause the user to feel high. A related cannabinoid (THC) not found in high amounts in hemp plants is what causes marijuana users to feel high.
When CBD enters your bloodstream, it interacts with the endocannabinoid system — a complex neurochemical network responsible for maintaining various homeostatic functions in the body. This includes pain perception, immune response, temperature control, memory, mood, hunger, fertility, inflammation, and much more.
While research on CBD and arthritis is in the early stage, current evidence coming from animal studies and several human trials suggests it may alleviate the symptoms of arthritis while resulting in virtually no side effects.
Animal Studies on CBD & Arthritis
- A 2011 study discovered that CBD was able to reduce inflammatory pain in rats by changing the way pain receptors react to stimuli.
- A 2014 review of the existing animal-based studies concluded that CBD may be effective for relieving osteoarthritis.
- In a 2016 study, researchers found that CBD may relieve inflammation linked to arthritis in problematic areas when applied topically.
- A 2017 research paper suggested that CBD was a safe and effective treatment option for osteoarthritis joint pain.
The big question is whether these results can be replicated in actual human trials. Interestingly, this seems to be the case!
Clinical Trials on CBD & Arthritis
- In 2006, the first study on cannabinoids and rheumatoid arthritis concluded that a pharmaceutical CBD-enriched cannabis extract called Sativex had a “significant analgesic effect” in arthritis patients. Researchers reported that pain and inflammation were significantly reduced throughout the treatment despite having almost no reported side effects.
- A 2008 study involving cannabinoids in the management of chronic pain discovered that CBD offered effective pain relief and improved sleep quality in the test group.
- A 2016 analysis of human trials for rheumatoid arthritis, osteoarthritis, and fibromyalgia also found that CBD resulted in a reduction in joint pain and improvement in irregular sleep patterns caused by chronic pain.
CBD Oil For Sale: Where To Find High-Grade CBD Oil
Most people look for CBD oils online — myself included. Don’t get me wrong, it’s possible to find high-quality CBD oil in a local dispensary, but I’ve found online to offer a greater range of products, and quite frankly, better prices.
I recommend you check out the company websites listed in the section at the top of this article, or do your own research using the tips listed in the section below to find other reputable CBD brands online. Read reviews, and look for third-party testing before you buy the product to make sure it’s going to deliver on its promises.
Must-Know Details for People Buying CBD Oil for Arthritis
Knowing what to look for in the best CBD oil for arthritis will save you a lot of hassle — there are a lot of fly-by-night companies currently offering CBD oils with questionable quality, to say the least.
CBD is an emerging market, so it’s no wonder many companies want to capitalize on the booming trend before the dust settles and the industry stabilizes.
With such an abundance of different brands selling CBD in various forms, it’s important to find a trusted manufacturer who will ensure high standards for their products.
Here’s what you should pay attention to when shopping for CBD oil to help with your arthritis symptoms.
1. Hemp Source: Where is the Hemp Sourced?
Hemp plants are unique in that they will absorb and accumulate virtually any and all elements in the soil and air in which it’s grown — this includes both the good stuff and the bad stuff.
Plants grown in contaminated soils will often contain harmful levels of heavy metals like cadmium, lead, or mercury. For this reason, it’s important you look for products that have been grown in regions with little contamination — such as America or Canada.
Some companies source cheap hemp from India or China to cut costs — which are notoriously high in toxic heavy metal contaminants.
I prefer oils made from American-grown hemp because of the high standards here that prevent farmers from growing food or supplementing crops in contaminated soils or polluted air.
The best hemp comes from USDA-certified organic farms — but these are hard to come by at the moment.
2. Extraction Method: Did The Company Use Toxic Solvents to Make the Oil?
Most reputable companies use CO2 for making their CBD oil. Pressurized CO2 works as a solvent that pulls CBD and other compounds from the plant material. When the pressure is released, the CO2 evaporates completely, leaving no trace of harmful chemical solvents in the final product.
This is in opposition to the conventional extraction methods — which use toxic solvents to strip the cannabinoids from the plant material such as hexane, propane, butane, or ether. If these solvents are used they need to be evaporated out. Oftentimes, small amounts of these chemicals will remain in the final product which can cause many unwanted side effects to people using the oil.
3. Cannabinoid Spectrum: Could There be any THC in the Final Product?
The next thing to look at is the cannabinoid profile of the oil. This refers to the amount of CBD and other cannabinoids in the final product.
There are three main categories here:
- Full-spectrum extracts — these oils contain many different cannabinoids aside from just CBD
- Broad-spectrum extracts — these oils contain many cannabinoids with the exception of THC
- CBD isolates — these oils contain only one cannabinoid — CBD
Many experts argue that full-spectrum CBD oil is better for arthritis-related inflammation. A 2016 Israeli study found that unlike pure CBD isolate, full-spectrum extracts offered more reliable benefits for arthritis sufferers. However, there are benefits to using broad-spectrum or isolate-based products as well.
4. Route of Administration: How is the Oil Intended to be Used?
CBD comes in a few different forms and can be used in several different ways:
- Sublingual — placed under the tongue for fast absorption
- Edibles — helps mask the flavor of hemp oil bit has a slower onset of effects
- Vape liquids — used in vape pens to inhale the CBD for absorption via the lungs
- Topicals — applied directly to the skin for localized relief
Generally, the best CBD products for arthritis are going to be a combination of topical CBD and oral CBD. I rub CBD-infused joint cream on the affected area first and then use CBD oil sublingually for the fastest onset of effects. I know a few other people that prefer to use a CBD-infused vape pen and CBD topicals to relieve arthritis.
5. Third-Party Testing: Does the Company Provide Transparency for its Claims?
Every company has the option to send a batch of their product to a third-party laboratory for content analysis. In order to be considered a third-party lab, it needs to have no affiliation with the manufacturer — allowing for a completely unbiased assessment of the products in question.
These laboratories measure the potency of CBD, scan the entire cannabinoid profile of the product, and can detect over 200 common contaminants.
This form of testing offers transparency on the quality and potency of the product. If you can’t find third-party testing to confirm the CBD oil you’re looking at contains exactly what the company says it does — I recommend you look elsewhere until you find a company that publishes this data publicly. It’s the only way to ensure the product you’re buying is going to be safe and effective.
What’s the Ideal CBD Dosage for Arthritis?
There is actually no one-size-fits-all dosage of cannabidiol when it comes to inflammatory pain caused by arthritis. The dose will vary a lot from one person to the next.
However, information gathered from CBD users suggests that most arthritis sufferers take around 25 mg of CBD in the form of an oil twice a day. You may need to increase or decrease this dose depending on how you respond to the oil. Most people shouldn’t expect any improvement in the first couple of days.
If you don’t feel any difference, gradually increase the amount of CBD oil until you find an effective dose.
Final Thoughts on Using CBD Oil for Arthritis
So far, research investigating the benefits of CBD oil for arthritis shows promising results. More research is needed to fully understand the role CBD and other cannabinoids play in alleviating arthritis-related pain and inflammation.
Although a large share of the studies currently available come from animal models. There are only a handful of good-quality clinical trials (double-blind and randomized). Of the few we have available in the scientific literature, all have shown notably positive results from the treatment group using CBD rather than placebo.
With all that said, it’s important to remember that CBD isn’t an overnight fix to all your problems, and in more serious cases, it may need some time to make the impact you’re looking for.
If you’re planning to use CBD oil for arthritis, consult your doctor first to discuss any potential interactions with other underlying health conditions or medications you may be taking.
Have you used CBD oil for arthritis symptoms? Post your results in the comment section below!
- Schuelert, N. & Mcdougall, J.J. (2011). the Abnormal Cannabidiol Analogue O-1602 Reduces Nociception in a Rat Model of Acute Arthritis Via the Putative Cannabinoid Receptor Gpr55., Neuroscience Letters, 500(1), 72–76.
- La Porta, C., Bura, S.A., Negrete, R., Maldonado, R. (2014). Involvement of the Endocannabinoid System in Osteoarthritis Pain. The European Journal of Neuroscience, 39(3), 485–500.
- Philippot, H.T., O’Brien, M., McDougall, J.J. (2017). Attenuation of Early Phase Inflammation By Cannabidiol Prevents Pain and Nerve Damage in Rat Osteoarthritis. Pain, 158(12), 2442–2451.
- Blake, D.R., Robson, P., Ho, M., Jubb, R.W., McCabe, C.S. (2006) Preliminary Assessment of the Efficacy, Tolerability and Safety of a Cannabis-based Medicine (Sativex) in the Treatment of Pain Caused by Rheumatoid Arthritis. Rheumatology (Oxford), 45(1), 50–52.
- Russo E. B. (2008). Cannabinoids in the Management of Difficult to Treat Pain. Therapeutics and Clinical Risk Management, 4(1), 245–259.
- Fitzcharles, M.A., Baerwald, C., Ablin, J., Hauser, W. (2016). Efficacy, Tolerability and Safety of Cannabinoids in Chronic Pain Associated With Rheumatic Diseases (fibromyalgia Syndrome, Back Pain, Osteoarthritis, Rheumatoid Arthritis): a Systematic Review of Randomized Controlled Trials. Schmerz (Berlin, Germany), 30(1), 47–61.
- Gallily, R., Yekhtin, Z., Lumir, O.H. (2015). Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology & Pharmacy, 6, 75–85.
Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
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10 Best CBD Oil for Arthritis: Top CBD Brands Reviewed 2022
Arthritis is a severe and debilitating condition that can affect people of all ages (although it’s more prominent in older individuals). The latest statistics from the Centers for Disease Control (CDC) reveal that up to 58.5 million Americans over 18 had some form of arthritis in 2015.
But an aging population coupled with the repetitive daily tasks we perform—such as computer work or physical labor – likely means the number will be much higher now in 2022. Alarmingly, the CDC predicts that arthritis patients will hit 78.4 million by 2040.
Numbers aside, it’s pretty clear that arthritis poses a considerable risk to people’s health, and it’s not going away anytime soon.
Although research is still ongoing, there’s strong anecdotal and preliminary evidence suggesting CBD may help address some of the symptoms associated with arthritis. As a result, cannabidiol may be a viable alternative for those concerned about medication side effects or dependence on painkillers.
To effectively address arthritis symptoms, you need a CBD oil that’s potent, pure, and safe. Unfortunately, there are now thousands of brands, making it hard to find quality products. We’ve compiled our ten best choices for CBD oil based on several benchmarks to measure quality, strength, safety, and transparency to narrow down the list.
Is CBD Oil Good for Arthritis?
We can’t conclusively say CBD oil is good for arthritis, but the ever-growing pile of preliminary research seems to support that conclusion. It’s also important to consider the mounds of anecdotal evidence that poured in long before experts took CBD seriously. Judging by the number of people who use CBD for arthritis pain and inflammation, the case for cannabidiol gets stronger every day.
For example, an Arthritis Foundation poll surveyed several arthritis patients, revealing some surprising information. According to the survey, 79% of respondents “are currently using CBD, have used it in the past or are considering using it.” Meanwhile, 29% say they currently use it for arthritis symptoms.
Interestingly, the products used are almost evenly split between oils and creams. Of the active CBD users polled, 62% use liquid CBD (oils, tinctures, beverages), while 55% use topical CBD products (creams, balms, lotions).
How CBD Oil Helps with Arthritis
If you plan to try CBD oil for arthritis, it’s helpful to understand how CBD oil helps with arthritis. The mechanism of action is a lot more complex than with other cannabinoids, like THC. But that’s one of the many reasons CBD is so versatile.
Most cannabinoids bind to the CB1 and CB2 receptors that form our endocannabinoid system. This network of receptors and internally-produced cannabinoids keeps our body in balance or “homeostasis.”
THC, for example, binds to both the CB1 and CB2 varieties. Some cannabinoids bind to one or the other. CBD, however, has little affinity for either. Instead, it works through different receptor pathways, including:
● GPR-55 orphan receptors
● TRPV1 vanilloid receptors
● PPAR receptors
● Serotonin receptors
Those pathways serve several functions, including pain regulation, appetite, sleep, and mood to name a few. In the case of arthritis, however, the TRPV1 or “vanilloid” receptors are primarily responsible for mitigating the condition’s symptoms. Researchers induced inflammation in rat subjects during a 2009 study published in the British Journal of Pharmacology.
Based on the observations, CBD’s interaction with the TRPV1 receptors contributed to the anti-inflammatory benefits that also helped reduce pain.
Inflammation is a textbook arthritis symptom inevitably accompanied by pain. Evidence suggests that CBD may help reduce joint pain related to arthritis. For instance, a 2017 research paper in the academic journal Pain studied the anti-inflammatory properties of CBD. Experts applied a CBD-infused topical on rats with osteoarthritis. Although the rodents didn’t show immediate improvement, observers noticed a significant reduction in inflammation by the 14th day of their experiment.
Analgesic 2019 Gallup poll shows 14% of Americans use CBD. But out of all the potential symptoms, 40% of those CBD consumers—the most significant chunk—use it for pain.
This pattern is even more prominent when you look at the Arthritis Foundation’s poll we covered earlier. That survey determined 94% of CBD users with arthritis took cannabidiol for pain.
But one notable piece of research is a 2008 review of existing literature by famous cannabis researcher and medical expert Ethan Russo. Russo is known for “Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects,” a paper where he proposed and explained the synergistic “entourage effect” that we frequently refer to today.
Russo examined studies on synthetic (prescription) cannabinoids and external cannabinoids (phytocannabinoids). Unsurprisingly, he concluded that, based on existing evidence, CBD and other cannabinoids might help manage chronic pain.
CBD was far from mainstream in 2008, but subsequent research—such as that mentioned above—has helped support Russo’s conclusions.
Best CBD Oil for Arthritis: Top CBD Brands Reviewed
If you’re looking to try full-spectrum CBD oil for arthritis pain, it’s hard to find the right product—especially if you’re new to CBD. You need a clean, tested, potent CBD oil for the best results.
To help determine the best CBD oil for arthritis, we’ve compiled a list of top ten vendors based on our objective benchmarks (more on that later).
1. Colorado Botanicals: Best CBD Oil for Arthritis
Colorado Botanicals was established in 2017, offering a trustworthy and effective line of inexpensive Full and broad-spectrum CBD products. Today, they carry an even more extensive selection of hemp supplements, but they have never wavered from their commitment to transparency, safety, and quality. We’re proud to give Colorado Botanicals our top spot as the Best CBD Oil for Arthritis.
Colorado Botanicals offers the best CBD oil for pain (or other possible uses). But we’re not the only ones to notice. Observer and Discover Magazine chose Colorado Botanicals as their top pick as Best CBD Oil and Best CBD Oil for Pain, respectively.
But Colorado Botanicals advantage isn’t just what you see on their shelves. Behind the scenes, those products are backed by quality assurance, sustainable farming, independent testing, and lab-grade production.
CO2 extraction is becoming the primary approach to quality CBD oils. It leaves no trace solvents, making it cleaner – albeit more complicated – than other methods. Unfortunately, the process also destroys many terpenes, cannabinoids, and other beneficial compounds. Typically, vendors artificially add terpenes from other plants to make up for the loss.
However, Colorado Botanicals perfected a proprietary CO2 extraction technique followed by an unmatched purification process that maximizes terpene, cannabinoid, and flavonoid retention for an all-natural product.
Colorado Botanicals full-spectrum CBD oil ranges in potency from 300 to 3,000mg of CBD per 30 ml bottle, but their 750mg Full-Spectrum CBD Oil—at 25 mg/ml—is strong enough to meet the needs of an average CBD user.
The already low price gets better with repeat shipping at a 15% discount.
Based in Denver, Colorado, CBDistillery has grown by leaps and bounds since its founding in 2016. CBDistillery focuses on quality sourcing. They use Colorado hemp grown through “natural farming practices,” although they never mention “organic.” The vendor is also certified by the U.S. Hemp Authority.
All of the company’s CBD oils are very affordable. Veterans and active military personnel may further offset the cost with CBDistillery’s 30% military discount.
Regular customers can also save money by subscribing to a 20% discount on every order.
CBDistillery offers excellent value along with a range of CBD extract products. However, we feel the best option is their mid-range product. CBDistillery’s 1,000mg Full-Spectrum CBD contains 33 mg/ml of CBD, allowing it to address mild to moderate symptoms.
3. NuLeaf Naturals
Established in 2014, NuLeaf Naturals keeps its products pure and simple. Although they were strictly CBD-focused, their offerings expanded to CBG, CBN, and CBC oils. NuLeaf’s approach to hemp CBD is similar to that of Colorado Botanicals. Both prefer to focus on purity rather than flavors and other proverbial bells and whistles. One thing they haven’t done is expand beyond oils, topicals, and capsules. But this isn’t necessarily a bad thing. Rather than branch out to new options, they continue refining and perfecting the products that made them successful. Unfortunately, this can limit their customer base, but those that are loyal can expect to enjoy some of the purest CBD oils available. If you’re looking to try Nuleaf Naturals CBD oil, their 900mg Full-Spectrum CBD Oil is a perfect mid-range starting point.
4. Lazarus Naturals
Based out of Seattle, Lazarus Naturals grows its organic hemp in Oregon.
They offer CBD and other cannabinoid extracts in various sizes and options. Like most premium CBD vendors, they’ve since expanded into other extracts, adding CBG and CBN to some of their formulations.
One thing that stands out about Lazarus Naturals is their price. Customers can pick up a bottle of full-spectrum 2,400 mg 60 ml CBD oil for just $120.00. Lazarus Naturals also has one of the best return policies possible. You can return your unwanted items for free with a prepaid shipping label up to 90 days after receiving them.
We recommend the Lazarus Naturals High Potency 1,500mg Tincture. All of the oil products in this line contain 50 mg/ml, so our choice is based on volume and price.
5. Charlotte’s Web
Charlotte’s Web is one of the most established CBD brands. Originally opening in 2012, their high-CBD cannabis strains put cannabidiol on the map. The brand rose to prominence after a story went public about Charlotte Figi, a young girl whose severe epilepsy was controlled by the company’s CBD oil.
Charlotte’s Web isn’t the cheapest brand, but it’s not prohibitively expensive either. It helps that they offer a 20% discount for subscribers and an assistance program for veterans.
Charlotte’s Web sells 30 or 100 mg bottles in 7, 17, 25, 50, and 60 mg/ml concentrations. In our view, however, the best mid-range choice is their THC-Free CBD Oil at 25 mg/ml. The broad-spectrum product is perfect for moderate users and carries no THC.
6. Joy Organics
Joy Organics is among the few who can say their hemp is USDA Certified Organic, the highest tier possible.
Like CoBo, Joy says they use a proprietary CO2 extraction method that maximizes natural hemp compound retention. Of course, you can see that with lab test results available on each product page.
The company also offers decent potency options, ranging from 15 mg/ml to 75 mg/ml – all at surprisingly affordable prices. Customers can save even more with Joy’s 20% discount for subscribers.
We highly recommend Joy Organics Full-Spectrum 1350 MG Fresh Lime Organic CBD Tincture, popular among customers looking to try CBD for arthritis pain.
At 45 mg per serving, the product’s potency offers an excellent balance for beginners and intermediate CBD enthusiasts.
cbdMD embodies what success in the industry should look like. Opening in 2015, their company grew exponentially and now offers a diverse selection of CBD oils, edibles, skincare products, and more.
As far as potency is concerned, cbdMD tops our list. Their most potent product (7500 mg) contains a staggering 250 mg/ml in a 30 ml bottle – far above the 100 mg/ml cap we’ve seen so far with other companies.
Considering what they offer, cbdMD is quite affordable, with their strongest oil retailing for just $209.99 – a price that’s much lower with their 30% subscriber discount. The cbdMD Premium 750 mg CBD Oil Tincture is a solid medium-dose product that may help people who are trying to address arthritis pain and other symptoms. At 25 mg/ml, the concentration isn’t excessive for beginners yet also adequate for those with moderate needs.
Established in 2017, Medterra is a bit of a youngster compared to some of its competitors. But despite its comparative inexperience, the CBD company has a lot to offer. Medterra only carries a handful of CBD products, but their formulas reflect the more advanced recipes that many companies adopted. Certain lines include other beneficial ingredients, like CBG and nutritional supplements.
What truly stands out about Medterra is its commitment to education. Their site is crammed with resources and news for beginners new to CBD. With such tools, it’s easy for anyone to get their feet wet as they enter the ever-growing world of hemp-derived CBD health supplements.
Customers looking for full-spectrum CBD oil can choose Medterra’s True Full-Spectrum oil at 50 mg/ml. The product is only available in 50 and 100 mg/ml doses, with 2 mg of THC per serving.
9. Royal CBD
Royal CBD’s commitment to quality is pretty straightforward. As their slogan states: “no room for mediocrity,” it’s evident that they take their products seriously. Despite the rather intense tone, it offers a sense of reassurance. Their commitment to quality is transparent, with CO2 extraction, natural sourcing, and third-party tests integral to their business.
Royal CBD offers decently potent oils. At up to 83 mg/ml in broad-spectrum and full-spectrum CBD options, they sit in the upper tiers but don’t approach the solid 100 mg/ml of CoBo, or cbdMD’s 250 mg/ml concentration.
Royal CBD’s 1,000 mg Full-Spectrum CBD Oil is a good balance between price and potency – although, at $129.00, it’s a bit expensive. Still, the product contains 33 mg/ml of CBD, an excellent mid-sized dose.
10. Green Roads
Green Roads may not have the same chops as some bigger names, but it makes up for that with its experience, knowledge, and exciting backstory.
Founded in 2013 by pharmacist Laura Fuentes, she was inspired to enter the industry after a friend with health issues approached her for help. What started as a side gig formulating products in her spare time soon became the thriving business we see today.
Green Roads carries isolate, broad-spectrum, and full-spectrum tinctures. We recommend Green Roads 1500mg Broad Spectrum CBD Oil, which contains a solid 50 mg/ml of CBD.
How We Chose the Best CBD Oil for Arthritis
Whether you’re looking for arthritis pain or other chronic pain management, you need the best CBD products. But sorting through the sea of companies is challenging and time-consuming – so we did that for you.
To remain objective, our rankings are based on a specific set of criteria, which determines a CBD vendor’s rank on our list.
An easy way to find the best CBD companies is through company reputation. It’s easy for any CBD retailer to say they’re the best or post reviews on their websites. However, we avoid potentially biased sources and instead focus on independent forums, like Reddit or Trustpilot.
That being said, some companies – while excellent – are still building a place in the market, so company reputation doesn’t carry the same weight as some of our other benchmarks.
Third-Party Lab Reports
Third-party lab reports are necessary for a CBD retailer to make it anywhere near our list. These tests are critical for transparency and safety. Without concrete proof, any vendor can assure us of their products’ quality, accuracy, and purity.
Lab reports should be clear, easy to read, and from a reputable third-party lab. Some vendors do their in-house testing, but that’s a recipe for bias. The tester’s information is supposed to be listed on the test document, making it easy to check with a simple Google search.
Product testing is tied to third-party lab reports. Lab reports won’t exist without a testing process – unless they’re forged, which sadly has been known to happen. Like reports, testing is an absolute must-have. Hemp extracts can contain any number of contaminants, like bacteria, fungi, and heavy metals. It’s also impossible to confirm CBD content without testing the extract first.
Any vendor that doesn’t test its products should be avoided.
While company reputation focuses on brand recognition through customer volume, customer reviews determine whether a vendor—known or obscure—is worth supporting. Again, we base our evaluations on independent feedback from sources like Reddit or other consumer review forums.
Although we understand every company has its share of bad ratings, a large customer base and overwhelmingly positive responses indicate a reputable business.
CBD Oil for Arthritis FAQs
How much CBD oil to take for arthritis?
The amount of CBD oil to take for arthritis is tricky to determine. Conventional medications receive extensive study and are designed to behave a certain way, making dosing easy and predictable.
CBD, however, hasn’t had the same level of research as any medicine you’ll find at your local drugstore – prescription or otherwise. And the information we do have only indicates that textbook CBD dosing is all but impossible.
Many factors affect the correct dose, including:
● Sensitivity (to CBD)
Our endocannabinoid systems are also unique to each of us, further complicating the dosing issue.
Start Low and Go Slow
CBD is biphasic, meaning that too much CBD is just as ineffective as taking too little. That’s why it’s essential to follow the old cannabis adage, “start low and go slow.” If you’ve never experienced CBD before, start with the smallest dose possible – around 2.5 to 5 mg. Increase that dose gradually over several days until you notice results.
When is the best time to take CBD oil for arthritis?
If you suffer from constant flare-ups, your goal will be to keep a steady supply of CBD in your body to hopefully mitigate the pain and inflammation. There’s no right or wrong time to take CBD, but consumers find it works better when taken with food.
Eating something fatty, like peanut butter, also helps speed up absorption since CBD (like all cannabinoids) needs some kind of lipid to carry it.
What is the best way to take CBD for arthritis?
The best way to take CBD for arthritis is through oral ingestion. This approach allows CBD to provide a more generalized anti-inflammatory and analgesic effect. Oils aren’t the only option. Many CBD edibles are available that make taking CBD easier for those who aren’t fans of the “hempy” oil flavor. To that end, CBD gummies are a fantastic alternative.
If you want the best CBD gummies for pain, keep our benchmarks in mind while shopping around. However, topicals are also a practical option for fast, focal relief of joint pain and inflammation. Although they’re not as long-lasting as CBD oil, topicals work almost instantly, right where you need them.
Both oils and topicals are excellent products, but using them together is the best way to prevent arthritis symptoms and quickly address them should they arise.
Does CBD have side effects?
Yes, CBD has side effects. Fortunately, they’re rare and relatively mild. Some examples include:
● Appetite change
● Mood changes
One concern is CBD’s potential interaction with certain prescription medications, such as antiepileptic drugs (AEDs). If you’re on any medicines, speak to your doctor or specialist before trying CBD.
Conclusion: Best CBD Oils for Arthritis of 2022
It’s tough to find the best CBD oils for arthritis. Shopping for the right one can be overwhelming with so many products, brands, and sources. The easiest way is to look for specific indicators of quality, credibility, and safety.
But the world of cannabinoid hemp supplements is rapidly expanding. CBD laid the groundwork, which has since paved the way for other related products. Cannabigerol (CBG) several brands—like those above—created some of the best CBG oil available, which could further help mitigate arthritis symptoms.
While there’s no guarantee CBD will work for you, being a smart shopper increases your chances of seeing positive results.
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