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The Best CBD Oil Brands for Anxiety & Depression

In the past several years, CBD has become a popular and natural way for people to help manage their anxiety. What is the best CBD for anxiety? And how does CBD help with anxiety? In this article, we highlight our favorite brands of CBD for anxiety and provide important background information on how to use CBD oils to help manage anxiety and depression.

CBD stands for cannabidiol, and it is one of the active ingredients found in cannabis. Though CBD is a critical component in medical marijuana, most commercially available CBD products are derived from the hemp plant. These products are said to offer a range of personal health benefits, and one of the most significant of those benefits is relief from anxiety.

A Harvard report notes that CBD is commonly used as a way to manage anxiety symptoms, and that those who struggle with various mental health concerns may use CBD to help them combat sleeplessness.

But what does the science really say about using CBD oil for anxiety and depression? And for those who wish to use CBD products to help with anxiety, what are the best CBD for anxiety brands out there?

Does CBD Help for Anxiety?

Studies show that, while CBD doesn’t necessarily alter a person’s baseline anxiety level, it may be useful for reducing experiential anxiety. Indeed, research points to CBD as a potentially effective way to address the symptoms of seasonal affective disorder (SAD), generalized anxiety disorder (GAD), and post traumatic stress disorder (PTSD). Additional research indicates that CBD “has a promising role as alternative therapy in the management of anxiety disorders,” though more clinical testing is needed to verify safe dosage levels.

Based on the available evidence, CBD may potentially help manage the symptoms of anxiety, though it is not a cure. Be sure to consult with your primary care physician or mental health care provider before taking CBD for anxiety and depression if you have any questions or concerns.

Best CBD Oil for Anxiety in 2022

Each product featured here has been independently selected by the writer. You can learn more about our review methodology here. If you make a purchase using the links included, we may earn commission.

  • Best Overall – CBDistillery Strongest Full Spectrum – Spruce
  • Best Full Spectrum – NuLeaf Naturals
  • Best Organic – Cornbread Hemp

How We Chose CBD Product for Calming

When creating our list of the best CBD oils for anxiety and depression, we compared brands and products ib six specific categories.

  • Type of CBD — Does the brand use full spectrum, broad spectrum, or CBD isolate?
  • Strength — How many milligrams of CBD does the oil contain per recommended dose?
  • Source — Where does the get the hemp used in their hemp extract? Is it grown in the U.S.?
  • Flavor — Do they offer multiple flavors, and if so, do they use natural flavoring instead of artificial flavors?
  • Transparency — Is the product tested by an independent third-party lab and do they make the results easy to access?
  • Customer Experience — What are customers saying about the product and if it has helped them manage stress and anxiety?

Learn more about each of the CBD oils on our list below.

Our Complete Reviews & Opinions

Best Overall: CBDistillery

CBDistillery is known for high-quality, pure CBD products, and their full spectrum oil is a great choice to help you relax. All of their products are third-party lab tested and confirmed to be safe and effective. We like their Relief + Relax CBD oil because it is a full spectrum oil that provides plenty of additional active cannabinoids and plant compounds like CBG, CBC, and terpenes to give you the full benefits of the entourage effect.

  • CBD: Full Spectrum
  • Strength: 33 mg CBD per serving (1000 mg per bottle)
  • Hemp source: Colorado

Why buy: We love this strong full spectrum CBD oil for anxiety because it is sourced from non-GMO, U.S. Hemp Authority Certified hemp grown in Colorado. Taking CBD Relief + Relax in the morning may be a great way to support a sense of calm throughout the day.

Strongest Full Spectrum: Spruce

Spruce CBD oil checks all of the right boxes: it’s all-natural, made from USA-grown hemp, and is backed by rigorous third-party lab testing. You can get this lab-grade CBD oil tincture in a range of potencies, ranging from 750 mg to 2,400 mg per bottle. We like that Spruce CBD oil is all-natural, organic, vegan, gluten-free, and contains no artificial flavors, preservatives, or sweeteners. Note that Spruce products may be too strong for entry-level customers.

  • CBD: Full Spectrum
  • Strength: 25 mg to 80 mg of CBD per serving
  • Hemp source: Kentucky and North Carolina

Why buy: We love that Spruce offers some of the strongest full spectrum CBD products, including their extra strength formula with 80 mg of CBD per serving. We recommend it for experienced CBD users looking for powerful relief from feelings of anxiety and stress.

Best Full Spectrum: NuLeaf Naturals

NuLeaf Naturals CBD oil is about as natural as a CBD tincture can get. It’s made from organic hemp, it’s additive- and pesticide-free, and it’s carefully lab-tested by independent third-party labs. This Colorado-grown, full spectrum CBD offers the full benefits of hemp extract in a natural, organic product. It may be taken daily to help you manage stress and feelings of anxiety by promoting a sense of calm and wellness.

  • CBD: Full Spectrum
  • Strength: 30 mg of CBD per serving (1800 mg per bottle)
  • Hemp source: Colorado

Why buy: We love this strong full spectrum CBD oil because of its simplicity. It contains organic full spectrum hemp extract and organic virgin hemp seed oil. NuLeaf Naturals also provides a consistent concentration of CBD across all bottle sizes to make dosing easier.

Best Organic: Cornbread Hemp

To make their Distilled CBD Oil, Cornbread Hemp extracts CBD only from hemp flowers. This distillation allows the oil to maintain a full spectrum of cannabinoids, with a CBD-to-THC ratio of 27:1. Lower in THC than their Whole Flower oil, this product is better for finding comfort during the day while staying focused and alert. Cornbread Hemp CBD is USDA organic and offers a cleaner tasting oil than some whole plant extracts.

  • CBD: Full Spectrum
  • Strength: 50mg per 1mL serving
  • Hemp source: Kentucky
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Why buy: We love this Cornbread Hemp Distilled CBD Oil because it uses whole flower CBD extract for a cleaner product and milder taste. It may be a great way to help ease anxiety during the day without drowsiness or loss of focus. Plus, it’s USDA-certified organic with third-party, ISO certified lab tests on every batch.

Using CBD to Help With Anxiety & Depression: What the Research Says

As cited above, initial research has found that CBD has the potential to help manage the symptoms of anxiety in a variety of cases.

There is also clinical evidence to suggest that CBD can be a tool for managing panic attacks. Panic disorder (PD) impacts about five percent of the total global population, making the anxiolytic effects of CBD products potentially impactful on a widespread level.

There is even clinical evidence that CBD may help minimize the symptoms of obsessive compulsive disorder (OCD), a nervous condition that can be debilitating. Currently, OCD is treated primarily through cognitive behavioral therapy and antidepressants, but the recovery rate is exceedingly low. The prospect of CBD as an alternative intervention is potentially game-changing.

But how exactly does CBD impact those with anxiety conditions? The short answer is that products from the cannabis plant tend to have a strong, reactive effect with the endocannabinoid system, a molecular system that regulates many core functions of the body, including emotions. Cannabinoids can bind to receptors in the endocannabinoid system and modify the way they function, yielding a range of possible health benefits.

In fact, one study notes that “modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.”

While CBD may potentially help to manage stress and anxiety, it is not intended as a cure for anxiety or depression.

How to Choose CBD Oil for You

When you’re looking for the best CBD for depression and anxiety, it’s important to choose a product that is safe, effective, and natural. Here are some important things to keep in mind when shopping for CBD.

What to Look For

Always look for the following pieces of information when comparing CBD oils for anxiety: type of CBD, hemp source, strength, and lab testing. Below are more details on what each of these mean and why they matter.

Type of CBD

There are actually three different types of CBD extract, including full spectrum, broad spectrum, and CBD isolate. We typically recommend full spectrum products as the most effective, as they allow you to benefit from the full entourage effect of the hemp extract. However, if you undergo drug testing for work or are sensitive to THC, broad spectrum products offer many of the same benefits without the THC. This can also be important for those who find that THC negatively impacts their anxiety.

Hemp Source

The quality of the CBD is directly related to the source of the hemp used in a product. Always look for brands that use hemp grown in the U.S.A. We also recommend brands that use either USDA organic hemp or hemp grown using organic farming practices. This ensures that the plants do not contain any pesticides and or artificial fertilizers.

Strength

It’s important to know the concentration of CBD in a product so that you can take the appropriate dosage level. For those new to CBD, it’s generally recommended to start with a lower dose, 10 mg or less, and slowly increase the amount as you are comfortable to find the right level of relief. Extra strength products, with 30 mg or more per serving, are recommended for those who know how CBD will affect them. You can read more about the strongest CBD oils here.

Lab Testing

Only purchase CBD oils for anxiety that undergo independent third-party lab testing for quality and safety. This is critical to ensure that the product contains the correct levels of CBD and cannabinoids, and that it is free from toxins, heavy metals, or other harmful substances. The brands we recommend all make their lab test results available through QR codes on the product label or on their site.

How to Read Labels

When you check the label of any CBD product, look for information on the four key factors listed above. Labels should clearly state the type of CBD and if it was made with U.S. grown hemp. To evaluate the strength of the product, look for both the amount of CBD per bottle, usually in milligrams per 30 mL, as well as the amount of CBD per serving, usually in milligrams per 1 mL dropper.

Quality products should also include lab-testing certification and a way for you to verify the results for yourself. You can also look for industry certifications and seals from the USDA, Leaping Bunny, the GMO Project, and the U.S. Hemp Authority. Finally, take time to check the list of ingredients to make sure that you are not allergic to any of them. Most CBD oils use a carrier oil like hemp seed oil, olive oil, or MCT coconut oil.

How to Use

For most CBD oils, take a dose once or twice per day, depending on the amount. Some oils work better for daytime use and can be taken in the morning, while others are better suited for nighttime use to help you fall asleep. Again, if you are new to CBD, start with a low amount and slowly increase it to find the correct level to provide relief.

The amount of CBD needed may vary from person to person based on their level of anxiety and other health concerns. One thing that holds true across the board is that using CBD consistently is best for improving stress levels, as the compound builds up within the body, amplifying its effect. In other words, CBD may help you manage anxiety symptoms, but don’t expect it to take effect immediately.

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Safety & Side Effects

According to the Mayo Clinic, CBD is generally well-tolerated. There are, however, some mild side effects that can occur. These often result from taking too much CBD, and can include:

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue

Additionally, CBD can potentially interact with certain prescription medications, like blood thinners and certain forms of statins. Always check with your doctor if you plan to start using CBD alongside any prescription medications. No CBD product has been approved by the FDA to treat anxiety or depression, so be sure to do your own research on any product you choose to purchase.

Alternative Options

While CBD may be a great option to help supplement your anxiety management, it is not meant to cure or treat anxiety. If you are suffering from severe anxiety and depression, the best thing to do is speak with your primary care physician or a mental health professional. They may recommend things like cognitive behavioral therapy, journaling, exercise, yoga, or prescription medications to help.

If approved by your doctor, CBD for depression and anxiety may work with these other approaches to help you find relief and better manage stress.

Josh Hurst is a journalist, critic, copywriter, and essayist. He lives in Knoxville, TN, with his wife and three sons. As a writer and independent reviewer of CBD products, Josh covers the relationship between cannabis-based products and the human body. His writing has appeared in Health, Shape, and Remedy Review.

Medically Reviewed By:

Alan Carter
PharmD Scientific Advisor, Medical Reviewer, and Clinical Pharmacist
Adjunct Faculty, UMKC School of Pharmacy

Best CBD oil for anxiety and depression: Top 3 brands for 2020

Stress isn’t inherently negative. It’s designed to help us get out of or avoid dangerous situations — like coming face to face with a hungry tiger.

These forms of stress are only meant to be temporary. Once the danger is avoided, we return to normal and stress and anxiety disappear.

In the modern era, there are new causes of stress that our bodies aren’t adapted to handle.

Tight deadlines at work, financial concerns, and excessive use of our phones and computers are new causes of stress we can’t manage very well.

These newer forms of stress can go on for extended periods. They persist for days, weeks, months, or years — eventually leading to a collapse of our stress-response network.

When our stress-response system fails, we fall into cycles of chronic and severe anxiety and depression. At this point, we need medications or supplements to help break the cycle and get our health back on track.

One of the most popular and effective natural anxiety supplements today is CBD oil

This humble cannabis-extract has a powerful effect on our neurological systems — helping to keep us calm and relaxed, boost our mood, improve productivity, and restore our innate ability to resist daily stress.

Here are the three top-rated CBD oils on the market in 2020 for managing chronic anxiety and depression.

Best CBD oils for anxiety & depression: 2020 roundup

    – Award-winning, best CBD oil for anxiety & depression – Runner-up, quality product at a good price – Potent CBD, but only ships to the U.K,

1. Royal CBD Oil — Best full spectrum hemp extract

Product Details:
Total CBD 250 mg – 2500 mg
Available Flavors Natural, Berry, Mint, Vanilla
Potency (mg/mL) 8.5 – 85 mg/mL
Extract Type Full-spectrum

Most experts agree full-spectrum CBD products offer significantly better anxiety support than CBD isolates. This is because other compounds in the hemp plant support the effects of CBD and offer their own anxiety and mood-supportive benefits.

This is why Royal CBD is our top pick for anxiety or depression. These oils are made from a high-grade full-spectrum hemp extract that contains a wide range of active cannabinoids, terpenes, and other hemp-derivatives. Many of these compounds have been proven to offer separate anti-anxiety and anti-depressant benefits.

For example, Royal CBD oil is particularly rich in limonene — one of the primary anti-depressant compounds in the hemp plant. These oils are also rich in caryophyllene, pinene, and linalool — all of which have been independently proven to support healthy neurotransmitter production and improve mood.

Royal CBD oils come in four different potency options:

  • 250 mg — low-potency, suitable for mild anxiety levels
  • 500 mg — medium-potency, suitable for mild to moderate anxiety or depression
  • 1000 mg — high-potency, most popular option overall, ideal for moderate anxiety or depression
  • 2500 mg — ultra-high potency, best value overall, effective for all levels of anxiety or depression

All Royal CBD oils come in a selection of flavors to help cut the natural taste of hemp. You can get these oils in peppermint, vanilla, berry (raspberry), or a natural, unflavored version.

  • Available in low-potency (250 mg) all the way up to ultra-high potency (2500 mg)
  • Made with a premium full-spectrum hemp extract
  • Recommended by several online publications as the best CBD oil for sleep (CFAH, Weed News, We Be High, and more)
  • Not available in-store (online brand only)

2. Gold Bee CBD Oil — Best organic CBD oil

Product Details:
Total CBD 300 mg – 1200 mg
Available Flavors Unflavored, Honey
Potency (mg/mL) 10 – 40 mg/mL
Extract Type Full-Spectrum

Gold Bee CBD oils aren’t as potent as Royal CBD (up to 1200 mg per bottle). However, this company meets the same meticulous level of quality control as our top-rated brand.

All Gold Bee CBD products are independently verified to confirm the concentration of CBD is exactly as advertised on the bottle. The company also orders unbiased third-party testing to check the terpene levels of its oils — which is particularly impressive.

Some of the most notable terpenes found in Gold Bee CBD oils are humulene and lavandin — both of which activate a neurotransmitter in the brain known as GABA.

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GABA is an important neuroinhibitory compound that helps slow down electrical activity and reduce anxiety symptoms.

Gold Bee oils also contain other terpenes, such as limonene of pinene that offer anti-depressant effects.

Gold Bee oils come in three potency options:

  • 300 mg — low-potency, suitable for mild anxiety
  • 600 mg — medium potency, suitable for moderate anxiety and depression
  • 1200 mg — high-potency, most popular, ideal for most anxiety and depression

These oils are very potent for their class. The high terpene levels and purity of these oils make them stronger than other products with comparable CBD content. The 1200 mg bottle of oil feels similar to the effects of a 1500 mg bottle of oil, yet comes with the benefits of a lower cost.

Only people with the most severe forms of anxiety or depression may need to seek out a stronger CBD oil than Gold Bee has to offer.

  • Available in a delicious honey-flavored oil
  • Contains up to 1200 mg of CBD per ounce
  • Third-party tested for quality assurance
  • This oil has received awards from media outlets, including LA Weekly, and Observer
  • High product demand means these oils are sometimes out of stock

3. Blessed CBD Oil

Product Details:
Total CBD 500 mg – 1800 mg
Available Flavors Unflavored
Potency (mg/mL) 50 – 180 mg/mL
Extract Type Full-Spectrum

Blessed CBD oils are some of the most popular CBD oils in Europe — and for good reason.

These oils tick all the boxes for the characteristics that make a CBD oil useful for managing symptoms associated with anxiety and depression.

Each bottle contains a high potency of full-spectrum, organically-grown hemp extract. These oils are rich in various terpenes, cannabinoids, and other phytochemicals.

The organic status of the hemp used to make these oils are of particular importance. Synthetic nutrients and harsh pesticides used on non-organic farms can damage the trichomes on the hemp flowers — which is where most of the active ingredients are made.

For this reason, we always recommend you opt for organic hemp oils from reputable brands like Blessed CBD.

Blessed CBD oils are available in three different potencies:

  • 500 mg — medium-potency, suitable for mild to moderate anxiety or depression
  • 1000 mg — high-potency, most popular, suitable for most anxiety and depression symptoms
  • 1800 mg — ultra-high potency, ideal for just about any level of anxiety or depression

The only downside to Blessed CBD is that they’re a U.K. brand only — meaning you won’t be able to order these oils if you live in the U.S. We’ve included this brand as an option for our international readers. None of the other brands on our list ship internationally.

  • Exceptionally high potency CBD oil
  • Full-spectrum and organic hemp extract
  • Extracted with supercritical CO2
  • Independently verified by an outside lab
  • Only available in the UK

CBD & Anxiety: How it works

Anxiety is the mental manifestation of stress.

As stress levels rise, hormones like cortisol cause electrical activity in the brain to increase. This makes us feel more awake and alert, but can also impact our ability to sleep, stay focused at work or school, or think clearly. It can also lead to panic attacks that can have debilitating side effects until the attack subsides.

Anxiety is primarily driven by two neurotransmitters in the brain — glutamate and norepinephrine. Both of these compounds work together to increase electrical activity and produce what we perceive as stress and anxiety.

Putting a stop to anxiety symptoms means slowing down this excessive electrical stimulation in the brain — which is exactly how CBD works.

CBD has been shown to support anxiety symptoms by reducing the effects of glutamate and norepinephrine. It blocks glutamate from activating its receptors and increases the activity of a separate neurotransmitter known as GABA.

GABA is important because it’s the primary inhibitory compound in the brain. It works in direct opposition to glutamate and norepinephrine, causing electrical activity to slow down. It’s responsible for reversing the stress response.

CBD & depression: How it works

Depression is a common side-effect of anxiety. Changes in electrical activity and neurotransmitter balance in the brain can dramatically change our mood.

Other key neurotransmitters, including dopamine and serotonin, fall out of balance from causes like chronic stress, insufficient sleep, or as a side-effect from certain prescription anxiety medications.

CBD has been shown to reduce depression by restoring neurochemical balance in the brain.

Scientific studies have consistently shown that cannabidiol extracts can reduce or eliminate common signs of depression.

These effects don’t happen overnight. CBD works best when used over long periods of time alongside other lifestyle changes — such as meditation, stress-management techniques, a healthy diet, regular exercise, and socializing with friends and family.

Final thoughts: Tips on choosing the best CBD for anxiety & depression

There are plenty of health supplements that can help with anxiety or depression — chamomile, kava, kratom, L-theanine, passionflower, and magnesium — just to name a few.

Few of these supplements can compete with the powerful calming action of a high-grade CBD oil.

This all-natural health supplement provides a robust set of benefits that are specific for regulating mood, easing stress levels, and supporting a more restorative sleep.

When shopping for CBD oils, it’s best to look for a product that employs a full-spectrum hemp extract, is made from organic hemp, and provides clear evidence of independent testing.

We recommend the high potency range from Royal CBD as the best anti-anxiety and anti-depressant CBD oil overall. The most popular option is the low-cost 1000 mg bottle of oil.

If you want the strongest CBD oil available, go for the 2500 mg option instead — you’ll be hard-pressed to find anything more potent.

The product recommendations in this article are made solely by the sponsor and are not recommendations made by VentureBeat. Sponsored articles are content produced by a company that is either paying for the post or has a business relationship with VentureBeat, and they’re always clearly marked. Content produced by our editorial team is never influenced by advertisers or sponsors in any way. For more information, contact [email protected].